The effect of emergency department pharmacists on drug overuse and drug underuse in patients with an adverse drug event (ADE)-related hospitalisation

The effect of a pharmacist-led medication review on reduction of drug overuse and drug underuse in patients with an ADE-related hospital admission after ED visit compared to regular care

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12506329

Enrollment

200

Registered

2022-03-06

Start date

2016-10-01

Completion date

Unknown

Last updated

2024-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patients visiting the emergency department with an adverse drug event Injury, Occupational Diseases, Poisoning

Interventions

Intervention group: regular care + the interdisciplinary intervention consists of a pharmacist-led medication review, patient counselling regarding medication, and information transmission to general

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 years and older were eligible for inclusion if they were hospitalised for more than 24 hours after visiting the ED.

Exclusion criteria

Exclusion criteria: 1. No communication possible due to condition or language barrier 2. Cognitive impairment; transfers to other hospital 3. No pre-admission medication; admission due to problems with cancer treatment 4. Alcohol intoxication and/or (self)poisoning related hospitalisation 5. Psychiatric hospitalisation 6. Intensive care unit (ICU) hospitalisation 7. Foreign tourist or homeless patient 8. Already included patient readmitted within the research period 9. Patients with no informed consent

Design outcomes

Primary

Measure	Time frame
The number of medication changes for drug overuse and drug underuse that took place during hospital admission and persisted six months thereafter measured using medication overviews and estimate the difference between groups with poisson regression analysis.	—

Secondary

Measure	Time frame
1. The number of all medication changes that took place during admission and persisted six months after discharge measured using medication overviews and estimate the difference between groups with poisson regression analysis. 2. The number of medication changes for drug overuse and drug underuse that took place during admission and all medication changes during admission measured using medication discharge records and estimate the difference between both groups with poisson regression analysis. 3. The proportion of ADEs causing hospitalisations recognised by physicians in the ED measured using discharge letters from the ED of intervention patients at moment of ED visit. 4. The degree of patient satisfaction with the intervention of the ED pharmacist measured in the intervention group using a Visual Analogue Scale (VAS) at three months after admission. 5. The number of (ADE-related) hospitalisations within a period of six months before and after the index admission within the intervention group measured using medical records from general practitioners and the difference between periods will be estimated by a Wilcoxon signed rank test.	—

Measure

Time frame

1. The number of all medication changes that took place during admission and persisted six months after discharge measured using medication overviews and estimate the difference between groups with poisson regression analysis. 2. The number of medication changes for drug overuse and drug underuse that took place during admission and all medication changes during admission measured using medication discharge records and estimate the difference between both groups with poisson regression analysis. 3. The proportion of ADEs causing hospitalisations recognised by physicians in the ED measured using discharge letters from the ED of intervention patients at moment of ED visit. 4. The degree of patient satisfaction with the intervention of the ED pharmacist measured in the intervention group using a Visual Analogue Scale (VAS) at three months after admission. 5. The number of (ADE-related) hospitalisations within a period of six months before and after the index admission within the intervention group measured using medical records from general practitioners and the difference between periods will be estimated by a Wilcoxon signed rank test.

—

Countries

Netherlands

Contacts

Public ContactRehana Rahman

r.n.rahman@umcg.nl+31 653854652

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 6, 2026