Management of Acute Malnutrition in Infants aged <6 months: Improving the evidence underlying new WHO Malnutrition Guidelines

Severe malnutrition in infants aged <6months – seasonal prevalence, outcomes and risk factors in Bangladesh: Repeat cross sectional surveys and a prospective cohort study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN12494235

Enrollment

1638

Registered

2017-11-09

Start date

2015-03-29

Completion date

Unknown

Last updated

2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Malnurishment Nutritional, Metabolic, Endocrine Malnurishment

Interventions

This study had two components. The first component is an observational study (an initial cross sectional survey among 742 infants<6m) conducted in Barisal Sadar upzila during the post-harvest season a

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Prevalence survey: Infants<6 months old. Prospective cohort study: Group A: 4-8 weeks old of either sex as ‘severe acute malnourished infant’ who have defined by weight-for-length <-3 z-score and or with presence of bilateral pitting oedema. Group B: 4-8 weeks old of either sex as not severely acute malnourished infant’ who have weight-for-length =-2 to <2 z-scores and absence of bilateral pitting oedema.

Exclusion criteria

Exclusion criteria: Prevalence survey: >6 months old infants. Prospective Follow-up Study: Other than the mentioned inclusion criteria

Design outcomes

Primary

Measure	Time frame
Prevalence survey: Prevalence rate of infants<6 months old suffering from acute malnutrition was measured by number of infants suffering from acute malnutrition among the infants considered for the surveys. Prospective Follow-up component: Proportion of infants in Group A still being as ‘severely acute malnourished’ and proportion of children in Group B has become ‘severely acute malnourished’ at the end of 6 mo of age (180 completed days).	—

Measure

Time frame

Prevalence survey: Prevalence rate of infants<6 months old suffering from acute malnutrition was measured by number of infants suffering from acute malnutrition among the infants considered for the surveys. Prospective Follow-up component: Proportion of infants in Group A still being as ‘severely acute malnourished’ and proportion of children in Group B has become ‘severely acute malnourished’ at the end of 6 mo of age (180 completed days).

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Secondary

Measure	Time frame
Prevalence survey: Secondary outcome variables were current feeding practices, mostly focusing on 24 hour recall. Prospective cohort study: 1. Mortality is measured as the proportion of initially well control infants who developed SAM at 6 months age; 2. Weight for length is measured as the changes in and absolute values of weight-for-length z-score (WLZ), weight-for-age z-score (WAZ), and length-for-age z-score (LAZ).	—

Measure

Time frame

Prevalence survey: Secondary outcome variables were current feeding practices, mostly focusing on 24 hour recall. Prospective cohort study: 1. Mortality is measured as the proportion of initially well control infants who developed SAM at 6 months age; 2. Weight for length is measured as the changes in and absolute values of weight-for-length z-score (WLZ), weight-for-age z-score (WAZ), and length-for-age z-score (LAZ).

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Countries

Bangladesh, England, Kenya, United Kingdom, United States of America

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026