Placental dysfunction Pregnancy and Childbirth
Conditions
Interventions
We will recruit pregnant participants at any point from 12+0 weeks' gestation up until delivery.
When recruited before 30 weeks' gestation, participants will be invited to up to three study visits du
Sponsors
Accord (United Kingdom)
Eligibility
Sex/Gender
Female
Age
16 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Aged 16-50 years 2. Able to give informed consent 3. Singleton non-anomalous viable pregnancy with gestational age >12 completed weeks 4. Pregnancy booked in NHS Lothian 5. No contraindication to MRI
Exclusion criteria
Exclusion criteria: 1. Women who are not pregnant 2. Aged under 16 or over 50 years 3. Women who are classified as Adults with Incapacity (AWI) as determined by midwife, GP, or research team 4. Multiple pregnancy 5. Diagnosed major congenital abnormality affecting fetal cardiovascular or nervous system 6. Contraindication to MRI (presence of non-compatible prostheses, implants, conductors or metallic foreign bodies, severe claustrophobia)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Placental and umbilical cord features, including measures of umbilical cord diameter and coiling and placental oxygenation, measured using ultrasound and MRI imaging at antenatal study visits (between 12+0 weeks' gestation and birth) | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood levels of angiogenic factors (PlGF and sFlt-1) measured using immunoassay at antenatal study visits (between 12+0 weeks' gestation and birth);Maternal and fetal Doppler indices and fetal biometry measured using ultrasound at antenatal study visits (between 12+0 weeks' gestation and birth);Macroscopic features and placenta and umbilical cord specimens measured using visual inspection at up to 24 hours after birth;Microscopic features of placenta and umbilical cord specimens measured using histological examination of prepared tissue sections at up to 3 months after birth;Clinical pregnancy outcomes measured using electronic health records at up to 2 weeks after birth | — |
Countries
Scotland, United Kingdom
Contacts
Public ContactRosemary Townsend
Outcome results
None listed