Induced sputum in children with cystic fibrosis

The contribution of induced sputum sampling to surveillance of lower respiratory tract microbiology in children with Cystic Fibrosis.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12473810

Enrollment

200

Registered

2018-01-10

Start date

2012-02-20

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Specialty: Children, Primary sub-specialty: Respiratory and Cystic Fibrosis Nutritional, Metabolic, Endocrine Cystic fibrosis

Interventions

Sputum induction will be paired with routine interventions for bacterial surveillance in children with cystic fbrosis, so that paired comparisons between sputum induction and standard approaches for p

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of cystic fibrosis 2. Under the care of South, West and Mid Wales Paediatric CF centre 3. Age 6 months – 18 years 4. Either gender 5. Attending for clinically indicated bronchoscopy (stage 2) 6. Not on treatment course of antibiotics

Exclusion criteria

Exclusion criteria: 1. Clinical grounds as defined by attending consultant 2. Previous serious reaction to hypertonic saline nebulisation

Design outcomes

Primary

Measure	Time frame
Stage 1: relative pathogen detection from sputum induction compared with cough swab Stage 2: relative pathogen detection from sputum induction compared to 1-lobe BAL, gold standard 2-lobe BAL and 6-lobe BAL	—

Secondary

Measure	Time frame
No secondary outcome measures	—

Countries

United Kingdom, Wales

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026