A ?omparison of the different regional anesthesia methods efficacy in chronic pain syndrom prevention in lung cancer surgery

Influence of regional anesthesia component on the rate of chronic post-thoractomy pain syndrome in lung cancer patients

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12472990

Enrollment

270

Registered

2018-02-01

Start date

2012-01-11

Completion date

Unknown

Last updated

2023-03-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic post-thoracotomy pain syndrome (CPTPS) is one of the most often side effects in lung surgery. After thoracotomy, its incidence ranges from 30% to 40%. The CPTPS is defined as pain that develops after surgical intervention and lasts for at least 2 months (International Association for the Study of Pain). The mechanism of the CPTPS is a long-lasting non-curable acute surgical pain associated with surgical trauma and inflammation of chest wall, lung and pleural parenchyma. For this reason,

Interventions

All consecutive patients scheduled for thoracotomy are randomly assigned to into three groups: 1) thoracic epidural anesthesia (TEA)

2) paravertebral nerve block (PVB) 3) intercostal nerve block (INB) using Research Randomizer (http://www.graphpad.com). In the TEA group, an epidural catheter is placed at T4-T6 inte

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: All consecutive patients scheduled for thoracotomy were screened for study inclusion using the following eligibility criteria: adult patients and ASA physical status from I to III.

Exclusion criteria

Exclusion criteria: 1. General anesthesia within 7 days before study inclusion 2. Administration of experimental drug within 30 days before surgery 3. Preoperative chronic postoperative pain syndrome 4. Acute unstable angina 5. Acute myocardial infarction documented by laboratory findings in the past 6 weeks 6. Heart rate (HR) < 50 beats per min (bpm) 7. Systolic blood pressure (SBP) < 100 mmHg 8. Heart block 9. Pre-operative vasopressor administration

Design outcomes

Secondary

Measure	Time frame
1. Intensity of APTPS and CPTPS between groups are measured using the Visual Analogue Scale (0 = no pain and 100 mm = worst possible pain) at 7 days, 1 and 6 months after surgery. 2. Pain is measured using the Visual Analogue Scale (0 = no pain and 100 mm = worst possible pain) at 7 days, 1 and 6 months after surgery	—

Primary

Measure	Time frame
1. Frequency and intensity of the CPTPS is measured using the Visual Analogue Scale (0 = no pain and 100 mm = worst possible pain) at 6 months after surgery 2. Effectiveness of TEA, PVB, and INB in CPTPS prevention are measured using the Visual Analogue Scale (0 = no pain and 100 mm = worst possible pain) at 6 months after surgery	—

Countries

France, Russian Federation

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026