Does resistance exercise with/without a nutrition supplement improve bone and muscle strength in women?

Efficacy of a targeted resistance exercise programme with and without leucine and vitamin D-enriched protein supplementation for preventing bone loss and improving muscle strength in older women: a randomised controlled trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12419961

Enrollment

Registered

2017-07-07

Start date

2017-06-24

Completion date

Unknown

Last updated

2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoporosis and sarcopenia Musculoskeletal Diseases

Interventions

Sixty women aged 65+ years will be randomised to one of three groups. The minimisation method of randomisation will be employed. The first participant will be fully randomised to an intervention and t

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Community-dwelling women aged 65 or over 2. Not currently engaged in upper body exercise training (within last 6 months) 3. Not using any medications for osteoporosis and not using any medications that can affect bone metabolism 4. Do not have an underlying disease that impairs bone metabolism, such as hyper/hypoparathyroidism, renal disease and malabsorptive conditions

Exclusion criteria

Exclusion criteria: 1. Currently engaged in upper body exercise training (or within last 6 months) 2. Using medications for osteoporosis 3. Using any medications that can affect bone metabolism 4. Have an underlying disease that impairs bone metabolism, such as hyper/hypoparathyroidism, renal disease and malabsorptive conditions 5. Recent forearm fracture (within the last 6 months)

Design outcomes

Primary

Measure	Time frame
1. Biochemical markers (serum measures of osteocalcin (bone turnover), C-terminal telopeptide (bone resorption), pro-collagen 1 intact N-terminal (bone formation), 25[OH] D (vitamin D), insulin-like growth factor-1), measured at 0 and 3 months 2. Bone mineral density of the forearm, measured using DXA at 0, 3 and 6 months	—

Secondary

Measure	Time frame
1. Bone mineral density of the spine and hip, measured using DXA at 0 and 6 months 2. Lean and fat mass, measured using DXA at 0, 3 and 6 months 3. Senior Fitness Test (hand grip, sit to stand test, gait speed over 6 m, and 6 minute walk test), measured at 0, 3 and 6 months 4. Wrist strength, measured using 30 sec wrist curl test at 0, 3 and 6 months Control outcomes 1. Lifetime physical activity and physical activity in the last 12 months, measured using the bone specific physical activity questionnaire at 0, 3 and 6 months 2. Dietary evaluation using a self-report 3-day diary at 0, 6, 12 and 18 weeks	—

Measure

Time frame

1. Bone mineral density of the spine and hip, measured using DXA at 0 and 6 months 2. Lean and fat mass, measured using DXA at 0, 3 and 6 months 3. Senior Fitness Test (hand grip, sit to stand test, gait speed over 6 m, and 6 minute walk test), measured at 0, 3 and 6 months 4. Wrist strength, measured using 30 sec wrist curl test at 0, 3 and 6 months Control outcomes 1. Lifetime physical activity and physical activity in the last 12 months, measured using the bone specific physical activity questionnaire at 0, 3 and 6 months 2. Dietary evaluation using a self-report 3-day diary at 0, 6, 12 and 18 weeks

—

Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026