Pleural mesothelioma Cancer
Conditions
Interventions
This is a prospective blinded comparative non-inferiority single-center feasibility study. Three radiologists will review every CT scan of adult patients with pleural mesothelioma referred to the tert
Sponsors
Antoni van Leeuwenhoek Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Histology or cytology-proven non-resectable pleural mesothelioma 2. Age =18 years 3. Availability of a baseline CT thorax with contrast before the start of new systemic treatment with a slice increment of =3 mm on the CT scan 4. Availability of at least one follow-up scan (the lungs must be fully contained in the image)
Exclusion criteria
Exclusion criteria: 1. CT scans with lungs not fully imaged 2. No histology-proven pleural mesothelioma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The interobserver agreement among experts employing the ARTIMES criteria and the gold standard (mRECIST v1.1 criteria), measured at the end of the study using kappa | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Time needed to measure response evaluation in minutes between the ARTIMES vs mRECIST v1.1 criteria, measured in minutes for every scan at every evaluation point 2. Time until partial response (PR) and progressive disease (PD) in days between the ARTIMES vs mRECIST v1.1 criteria, measured in days at every evaluation point 3. The response evaluation of the treating physician with the ARTIMES criteria and the mRECIST v1.1. criteria per evaluation point, compared at every evaluation point 4. The performance of the AI in segmenting pleural mesothelioma tumour volume vs the final segmentation of the reviewers, compared at every evaluation point | — |
Countries
Netherlands
Contacts
Public ContactIllaa Smesseim
Outcome results
None listed