Topic: Children
Conditions
Interventions
Phase 1: Samples will be collected by parents on the ward from their baby's nappy. The samples need to be 'fresh' (passed within an hour) and they will need to take three samples from the same 'dirty
Sponsors
University of Bristol
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Babies recruited antenatally or in the first 8 months of life born with Down's syndrome (three copies of chromosome 21) as confirmed by karyotype after birth
Exclusion criteria
Exclusion criteria: 1. Babies with Down's syndrome who have a child protection plan or who are no longer with their birth mother 2. Babies with Down's syndrome over 8 months of age 3. Babies with Down's syndrome in whom the parents do not speak English
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As a feasibility study the primary outcome is to have established a cohort of children with Down’s syndrome in which we have been able to record early feeding practice and obtain samples from which we can study the development and natural history of autoimmunity in relation to feeding and the gut microbiome. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparing babies with Down's syndrome who have breastfed with those that have not, we will be studying: 1. Whether they have significant differences in autoantibody status 2. Whether they have differences in the diversity of their gut microbiomes We would also be investigating the correlation between levels of anti-BSA antibodies and correlate with autoantibody positivity in all participants who had been exposed to cow's milk protein. | — |
Countries
England, United Kingdom
Outcome results
None listed