Investigating the levels of extrachromosomal circular DNA in serum of newly diagnosed type 2 diabetes mellitus patients

Pilot study to assess abnormal expression of serum extrachromosomal circular DNA between newly diagnosed type 2 diabetes mellitus patients and healthy participants.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN12415732

Enrollment

Registered

2020-12-21

Start date

2020-07-21

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Type 2 diabetes mellitus Nutritional, Metabolic, Endocrine Type 2 diabetes mellitus

Interventions

Peripheral blood samples will be collected from newly diagnosed type 2 diabetes mellitus patients and healthy participants. Serum DNA extractions were performed using QIAamp Circulating Nucleic Acid K

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Type 2 diabetes mellitus diagnosed according to the 1999 World Health Organization diagnostic criteria

Exclusion criteria

Exclusion criteria: 1. No clinical evidence of severe kidney or liver diseases, chronic viral or bacterial infection, in?ammatory diseases, tumors, or diabetic ketoacidosis

Design outcomes

Primary

Measure	Time frame
1. Serum eccDNA levels in peripheral blood samples of newly diagnosed type 2 diabetes mellitus patients measured using high throughput sequencing at the time of data collection	—

Secondary

Measure	Time frame
1. Clinical factors associated with the differentially expressed eccDNA measured using patient records at the time of data collection	—

Countries

China

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026