Malnutrition in people aged 75 years or older Nutritional, Metabolic, Endocrine Healthy ageing
Conditions
Interventions
Current interventions as of 08/01/2024 to 30/01/2020:
We aim to recruit approximately 7200 participants by a predominantly postal questionnaire from 250 general practices in order to identify at 1153
Sponsors
University of Southampton
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients aged > = 75 who are either living alone or have one or more major medical or social problem(s) known to increase nutritional risk. These are: 1.1 Chronic Obstructive Pulmonary Disease (COPD) 1.2 Cerebrovascular disease, including stroke 1.3 Cardiac failure 1.4 Chronic Kidney Disease (stage IIIb/IV/V) 1.5 Chronic gastrointestinal problems or chronic liver disease, including inflammatory bowel diseases and constipation (but excluding functional conditions e.g. IBS) 1.6 Recent hospital discharge in the last 3 months 1.7 Parkinson’s disease; current depression (in the last 12 months) 1.8 Excessive polypharmacy (10 or more medications) 2. A proportion of participants (n=1110) will be identified as being at high risk of malnutrition, based on their questionnaire answers (with a SNAQ score of less than 14 or who report losing at least 5Kg of weight in the previous 6 months, and whose estimated BMI is less than < 25), and in the intervention group only these individuals will be invited to screening and assessment 3. English needs to be good enough to understand the study materials, as funding for the trial does not allow for translation.
Exclusion criteria
Exclusion criteria: 1. Used ONS in the last 6 months 2. Terminal disease 3. Ongoing primary treatment for cancer 4. Diabetes 5. Established dementia (this group would be substantially different mandating involvement of the carers, and different outcomes) 6. Receiving established nutritional support 7. Unable to consent 8. Institutionalised patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Quality of Life using the SF-36 2. Infections - proportion experiencing an infection during the follow-up period | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Timed up and go test – baseline (for intervention pts) and 18 months all pts 2. Grip strength using a handgrip dynamometer (3 measurements from both hands)- baseline (for intervention pts) and 18 months all pts Baseline and 18 months for: 3. Current actual and/or estimated height and weight for BMI calculation, 4. Weight change (eg. Looser or tighter clothing/rings/belts) 5. Current / recent acute illness 6. Falls 7. Number of regular medications 8. SNAQ appetite questionnaire 9. Food frequency questionnaire 10. Geriatric Depression Scale (GDS4) 11. Wellbeing – WEMWBS 12. Psychological measures, informed by the logic model from the development phase of the study (self-efficacy, risk awareness, outcome expectancy) 13. Frailty (EFI) score 14. Optional urine samples and optional blood spot samples –the samples will be analysed to structurally annotate biomarkers of nutrient intake and frailty risk 15. Demographic questionnaire, including: Health service use and drugs, including taking ONS (prescribed or over the counter over the last year), taking multivitamins, details about recent hospitalisation, current drugs | — |
Countries
England, United Kingdom
Outcome results
None listed