Patients with documented multivessel coronary artery disease, documented ischemia by stress testing and preserved left ventricular ejection fraction (LVEF) Circulatory System
Conditions
Interventions
Ischemic preconditioning (IP) is a powerful cellular protection mechanism. The cellular pathways underlying IP are extremely complex and involve the participation of cell triggers, intracellular signa
Sponsors
Instituto do Coração
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Stable multivessel coronary artery disease (obstruction greater than 70% in at least 2 main coronary branches). 2. LVEF =0.50, confirmed by transthoracic Doppler echocardiography. 3. Documentation of stress-induced myocardial ischemia (horizontal or descending ST segment depression = 1.0 mm)
Exclusion criteria
Exclusion criteria: 1. Kidney failure (creatinine clearance < 60 ml/min) 2. Severe liver failure 3. Single-vessel coronary artery disease 4. Myocardial infarction in the last 3 months 5. LVEF < 50% 6. Presence of any non-ischemic cardiomyopathy 7. Moderate or severe valve disease 8. Morphological changes in the qrs of the ecg and conduction defects that may interfere with the interpretation of changes in the st segment 9. Recent and negative exercise test for myocardial ischemia 10. Positive exercise test for myocardial ischemia, with signs of high risk 11. Limiting anginal symptoms or recent worsening 12. Arrhythmias that make it difficult to characterize myocardial ischemia during exercise stress (atrial fibrillation or flutter) 13. Patient refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time required to achieve 1.0 mm of ST segment depression (T-1.0 mm) measured using the treadmill ECG stress test at baseline without dapagliflozin and 7 days with dapagliflozin | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Heart rate pressure product (RPP) measured using the treadmill ECG stress test at baseline without dapagliflozin and 7 days with dapagliflozin 2. Improvement of angina measured using the treadmill ECG stress test at baseline without dapagliflozin and 7 days with dapagliflozin | — |
Countries
Brazil
Contacts
Public ContactPaulo Rogerio Soares
Outcome results
None listed