Symptomatic carotid stenosis or carotid web Circulatory System
Conditions
Interventions
The study assesses the risk of vascular events, radiology findings and blood biomarkers in patients treated at or referred to the neurology clinic at Sahlgrenska, Gothenburg, Sweden.
Notable aspects
Sponsors
Region Västra Götaland
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1, 2 or 3 + 4 and 5: 1. Suspicion of symptomatic =50% carotid stenosis or occlusion 2. Symptomatic <50% stenosis (on all exams) that is considered for carotid surgery or stenting anyway, usually due to repeated symptoms despite best medical therapy 3. Carotid web, both symptomatic and asymptomatic 4. Treated at or referred to the neurology clinic at Sahlgrenska University Hospital 5. Informed consent
Exclusion criteria
Exclusion criteria: Does not meet the inclusion criteria
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Recurrent preoperative stroke, assessed clinically, from presenting event until carotid surgery or stenting 2. Postoperative stroke or death, assessed clinically, within 30 days of carotid surgery or stenting 3. Long-term vascular events including, stroke, TIA, myocardial infarction, new-onset angina, new-onset heart failure, new-onset symptomatic peripheral artery disease, arterial revascularization and vascular death. Assessed for 10 years by annual review of medical records and diagnosis registry searches at 5 and 10 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Diagnostic: Flow measured in internal carotid artery and several comparison arteries on preoperative phase contrast MRI 2. Diagnostic: Artery diameters in the stenosis, internal and external carotid arteries measured on preoperative CT-angiography 3. Diagnostic: Flow velocities measured in common carotid artery, the stenosis and distal to the stenosis on preoperative ultrasound 4. Prognostic: All ipsilateral ischemic events (stroke, retinal artery occlusion, TIA and amaurosis fugax) recorded between the presenting event and surgery/stenting 5. Prognostic: All-type stroke recorded preoperatively between presenting event and surgery/stenting 6. Pathophysiological: Collateral status assessed by flow direction assessment of intracerebral arteries on preoperative phase contrast MRI 7. Pathophysiological: Collateral status assessed by appearance (normal/small/not seen) of intracerebral arteries on preoperative CT angiography 8. Pathophysiological: Velocity and flow profiles of the common carotid artery, the stenosis and distal to the stenosis on preoperative ultrasound 9. Pathophysiological: Intraoperative measurements of stump pressure, flow, cerebral oxygenation (NIRS) | — |
Countries
Sweden
Contacts
Public ContactElias Johansson
Outcome results
None listed