Nerve and muscle disorders Nervous System Diseases
Conditions
Interventions
We plan to study healthy volunteers and two patient groups. We will discuss each in turn.
Healthy volunteers
We will recruit healthy volunteers via local advertisement of the study. Following consent
Sponsors
University of Exeter
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers 1.1. Male or female participants, aged 18-90 years 1.2. No known neurological diagnoses 1.3. No symptoms suggestive of weakness in the arms or legs 2. Patients under investigation for suspected motor neurone disease 2.1. Male or female participants, aged 18-90 years 2.2. Undergoing neurophysiological assessment for their symptoms, where one of the differential diagnoses includes motor neurone disease or its subtypes, e.g. amyotrophic lateral sclerosis, primary muscular atrophy, primary lateral sclerosis. 3. Patients with a diagnosis of inclusion body myositis 3.1. Male or female participants, aged 18-90 years 3.2. Diagnosis of inclusion body myositis meeting the 2024 ENMC Criteria
Exclusion criteria
Exclusion criteria: All participants: 1. Known bleeding/clotting disorder 2. Taking anti-coagulation medications, e.g. warfarin, direct oral anticoagulants. 3. Pregnancy 4. Lacks capacity to provide informed consent Healthy volunteers only: 1. Contraindication to MRI (as healthy volunteers may undergo an MRI scan of their muscles)
Countries
England, United Kingdom
Contacts
Public ContactJames;Alexander Alix;Dudgeon
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Outcome results
None listed