Silicosis Respiratory
Conditions
Interventions
We used blocking randomisation. Staff other than participants, care providers, outcome assessors, data analysts generated the random allocation sequence. Random numbers include 1 and 2.The patients we
Sponsors
Laizhou Chronic Disease Prevention and Treatment Hospital, Shandong Province
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age: 50 - 80 years old, gender not restricted 2. Diagnosed with stage II silicosis based on medical history and related examinations 3. Dust exposure = 5 years 4. Voluntary signing of the informed consent form
Exclusion criteria
Exclusion criteria: 1. Patients with a history of tuberculosis or those in the active stage of tuberculosis 2. Pulmonary tumors 3. Severe chronic obstructive pulmonary disease (GOLD level 4) 4. Estimated glomerular filtration rate (eGFR) lower than 30 milliliters per minute 5. Child-Pugh B/C grade 6. Pregnant women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Diffusion Lung capacity for CO measured using pulmonary function testing equipment after 6 months treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Forced vital capacity measured using pulmonary function testing equipment after 3 and 6 months treatment 2. Forced expiratory volume in one second measured using pulmonary function testing equipment after 3 and 6 months treatment 3. Diffusion Lung capacity for CO measured using pulmonary function testing equipment after 3 months treatment 4. Modified Medical Research Council measured using questionnaire after 3 and 6 months treatment 5. COPD Assessment Test measured using questionnaire after 3 and 6 months treatment 6. Walking distance measured using 6 min walk experiment after 6 months treatment 7. Serum IL-6 level measured using ELISA after 3 and 6 months treatment | — |
Countries
China
Contacts
Public ContactKang Xiao
Outcome results
None listed