Study into the control of blood pressure and antihypertensive medication withdrawal in haemodialysis patients by programmed reduction in dry weight

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12355432

Enrollment

Registered

2005-09-30

Start date

2005-04-01

Completion date

Unknown

Last updated

2015-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular: Hypertension Circulatory System Hypertension

Interventions

We propose to study 40 patients currently undergoing chronic haemodialysis in a randomised un-blinded prospective fashion. The first group will have their dry weight adjusted according to need as ass

Eligibility

Inclusion criteria

Inclusion criteria: Chronic haemodialysis patients

Exclusion criteria

Exclusion criteria: 1. Clinical Evidence of fluid overload (peripheral or pulmonary oedema) 2. History of major cardiovascular event within the last year (myocardial infarction, CVA and major peripheral vascular disease episodes) 3. Patients having either acetate free biofiltration or haemodiafiltration 4. History of interdialytic weight gains of greater than 4 kg 5. Haemoglobin (Hb) less than 8 g/dl 6. Autonomic neuropathy

Design outcomes

Primary

Measure	Time frame
Primary end points: 1. The number of patients attaining pre-dialysis BP < 140/90 with partial or total withdrawal of antihypertensive medication. 2. Incidence of hypotensive episodes	—

Secondary

Measure	Time frame
Secondary end points: 1. Correlation between satisfactory pre dialysis BP and 24 hour BP profile 2. Patient tolerability (symptoms)	—

Countries

United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026