Individuals at risk of type 2 diabetes Nutritional, Metabolic, Endocrine
Conditions
Interventions
The experimental conditions are:
1. High-intensity interval training (HIT)
2. Continuous training (CT)
3. Control (CON)
Sponsors
University of Leicester (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 16/05/2016: 1. Has had 2 hour glucose between 7.8mmol.L-1 and 11.1mmol.L-1 after an oral glucose tolerance test (performed at the Leicester Diabetes Centre as part of another study within 12 months) OR Has HbA1c between 5.7% to 6.49% within the last 5 years 2. Is of south Asian (Indian, Bangladeshi, Pakistani) or white European (British, Irish or other European country) descent 3. Adults aged between 50 to 74 years inclusive (subject to females being post-menopausal defined as no menstruation in the last 12 months as reproductive hormones interact with appetite hormone responses) 4. Able to walk and use treadmill 5. BMI =27.5kg/m2 (WE) or =25kg/m2 (SA) 6. Weight stable (weight has not fluctuated more than ±5kg in the last 6 months) 7. Ability to communicate in and understand English to participate in the informed consent process Previous inclusion criteria: 1. Has had 2 hour glucose between 7.8mmol.L-1 and 11.1mmol.L-1 after an oral glucose tolerance test (performed at the Leicester Diabetes Centre as part of another study within 12 months) OR Has HbA1c between 6%-6.49% at baseline or at their most recent blood test within the previous 12 months 2. Is of south Asian (Indian, Bangladeshi, Pakistani) or white European (British, Irish or other European country) descent 3. Adults aged between 50 to 74 years inclusive (subject to females being post-menopausal defined as no menstruation in the last 12 months as reproductive hormones interact with appetite hormone responses) 4. Able to walk and use treadmill 5. BMI =27.5kg/m2 (WE) or =25kg/m2 (SA) 6. Weight stable (weight has not fluctuated more than ±5kg in the last 6 months) 7. Ability to communicate in and understand English to participate in the informed consent process
Exclusion criteria
Exclusion criteria: Current exclusion criteria as of 16/05/2016: 1. Regular purposeful exercise (=3 x 20 minute bouts of self-reported vigorous exercise performed per week) 2. Individuals who stand for extended periods of time (standing has been shown to improve glycaemic variability) 3. Mixed race (including individuals of mixed race would prevent determination of whether ethnicity is a modifying factor in the response to HIT) 4. Use of any glucose lowering medication 5. Dieters/restrained eaters (as assessed using the 3 factor eating QA) 6. Any contraindications to exercise such as abnormal resting ECG, breathlessness or dizziness on exertion, poor circulation, hypo- or hypertension 7. Significant renal or hepatic impairment defining parameters i.e. chronic kidney disease stage 3b, liver markers more than 3x greater than the normal range 8. Consent not given to contact GP with test results Previous exclusion criteria: 1. Diagnosed type 2 diabetes 2. Regular purposeful exercise (=3 x 20 minute bouts of self-reported vigorous exercise performed per week) 3. Individuals who stand for extended periods of time (standing has been shown to improve glycaemic variability) 4. Mixed race (including individuals of mixed race would prevent determination of whether ethnicity is a modifying factor in the response to HIT) 5. Use of any glucose lowering medication 6. Dieters/restrained eaters (as assessed using the 3 factor eating QA) 7. Any contraindications to exercise such as abnormal resting ECG, breathlessness or dizziness on exertion, poor circulation, hypo- or hypertension 8. Significant renal or hepatic impairment defining parameters i.e. chronic kidney disease stage 3b, liver markers more than 3x greater than the normal range 9. Consent not given to contact GP with test results
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incremental glucose area under the curve: blood samples taken at -1h, 0h, 0.5h, 1h, 2h, 3h, 3.5h, 4h, 5h, 6h, 7h throughout each treatment day will be analysed for glucose concentration using a glucose oxidase method | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Questionnaires: RPE, positive mood/affect, sleepiness, appetite 2. Blood markers: IL-6, CRP, insulin, leptin, ghrelin, acylated ghrelin, PYY3-36, GLP-1, Selenoprotein-P, LECT2, Follistatin, Fetuin-A, FGF21 3. Blood pressure These measures will be taken at -1h, 0h, 1h, 1.5h, 2h, 3h, 3.5h, 4h, 5h, 6h, 7h | — |
Countries
England, United Kingdom
Contacts
Public ContactTom Yates
Outcome results
None listed