Optimisation of invasive breathing support in newborns by continuous carbon dioxide monitoring

Optimising mechanical ventilation in newborns using capnography

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12331315

Enrollment

200

Registered

2018-11-01

Start date

2018-11-28

Completion date

Unknown

Last updated

2022-10-31

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Mechanical ventilation in newborns Respiratory Mechanical ventilation in newborns

Interventions

A side stream capnograph will be integrated with the ventilator circuit for the whole time the infant is receiving invasive mechanical ventilation. In order to validate the side steam capnography agai

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Neonates 2. Invasively mechanically ventilated 3. Admitted to the neonatal intensive care unit 4. Written parental consent

Exclusion criteria

Exclusion criteria: 1. Non ventilated infants 2. Infants on non-invasive respiratory support

Design outcomes

Primary

Measure	Time frame
Decrease in the complications of mechanical ventilation and decrease in the frequency of blood sampling in ventilated newborn infants.; Timepoint(s): . The following are recorded throughout the period the infant is receiving invasive mechanical ventilation: 1. Frequency of complications of mechanical ventilation (pneumothorax, blocked or dislodged endotracheal tube, hypo or hypercarbia), 2. Frequency of routine blood gas sampling These will be compared to historical controls who were invasively mechanically ventilated prior to the use of routine end tidal capnography monitoring.	—

Measure

Time frame

Decrease in the complications of mechanical ventilation and decrease in the frequency of blood sampling in ventilated newborn infants.; Timepoint(s): . The following are recorded throughout the period the infant is receiving invasive mechanical ventilation: 1. Frequency of complications of mechanical ventilation (pneumothorax, blocked or dislodged endotracheal tube, hypo or hypercarbia), 2. Frequency of routine blood gas sampling These will be compared to historical controls who were invasively mechanically ventilated prior to the use of routine end tidal capnography monitoring.

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Secondary

Measure	Time frame
1. Validation of side stream capnography with mainstream capnography and arterial carbon dioxide levels, ascertained by correlation of values in kPa during a twenty-minute validation period 2. Anatomical and alveolar dead space, calculated in mechanically ventilated infants with four neonatal respiratory conditions: 2.1. Respiratory distress syndrome 2.2. Evolving bronchopulmonary dysplasia 2.3. Meconium aspiration syndrome 2.4. Persistent pulmonary hypertension of the newborn These will be calculated by analysing carbon dioxide waveforms using the Bohr/Enghoff equation once the infant is no longer receiving mechanical ventilation.	—

Measure

Time frame

1. Validation of side stream capnography with mainstream capnography and arterial carbon dioxide levels, ascertained by correlation of values in kPa during a twenty-minute validation period 2. Anatomical and alveolar dead space, calculated in mechanically ventilated infants with four neonatal respiratory conditions: 2.1. Respiratory distress syndrome 2.2. Evolving bronchopulmonary dysplasia 2.3. Meconium aspiration syndrome 2.4. Persistent pulmonary hypertension of the newborn These will be calculated by analysing carbon dioxide waveforms using the Bohr/Enghoff equation once the infant is no longer receiving mechanical ventilation.

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Countries

England, United Kingdom

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026