Use of autologous blood products to enhance the survival of corneal transplants

Safety and efficacy of brief intraoperative incubation of full-thickness corneal grafts in autologous plasma products for reducing postoperative endothelial cell loss

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12328428

Enrollment

Registered

2023-07-28

Start date

2021-06-28

Completion date

Unknown

Last updated

2025-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of corneal endothelial cell loss after penetrating keratoplasty Eye Diseases

Interventions

Prospective randomized trial of patients undergoing penetrating keratoplasty by three surgeons. Participants who agreed to undergo intervention were randomly assigned by block randomisation to either

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Patients older than 18 years 2. Undergoing penetrating keratoplasty for any reason by the previously mentioned surgeons from June 2021 to December 2022 3. All the tissue was provided by the same Eye Bank (COBANCOL), with no more than 14 days of preservation

Exclusion criteria

Exclusion criteria: 1. Tissue from another institution operated by other surgeons 2. Patients from vulnerable populations. 3. Patients with renal failure, anemia, or immunosuppressed 4. Patients with previous trabeculectomies or glaucoma valve implants

Design outcomes

Primary

Measure	Time frame
Postoperative endothelial cell loss using endothelial cell counts on specular microscopy at 1st, 3rd, and 6th postoperative months	—

Secondary

Measure	Time frame
1. Hexagonality measured using specular microscopy at 1st, 3rd, and 6th postoperative months 2. Corneal thickness using specular microscopy at 1st, 3rd, and 6th postoperative months	—

Countries

Colombia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026