Renal, Kidney perfusion, Magnetic resonance imaging Urological and Genital Diseases Chronic kidney disease
Conditions
Sponsors
NHS Greater Glasgow and Clyde (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years 2. Written informed consent 3. CKD - people with chronic kidney disease stages 3 - 5, with an eGFR 15-30ml/min 4. LKD - people being assessed to act as live kidney donors 5. RVD - people with renovascular disease documented on imaging and after assessment by a nephrologist
Exclusion criteria
Exclusion criteria: 1. Known liver disease (alcoholic liver disease, hepatitis, cirrhosis) 2. Known HIV infection 3. Known recreational drug or alcohol abuse 4. Clinical signs of acute infection 5. Known pregnancy 6. Women of childbearing age are who are at risk of pregnancy 7. Metal prosthesis contraindicating MRI 8. Claustrophobia contraindicating MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in renal perfusion by ASL MRI, measured after saline and then after ascorbic acid | — |
Secondary
| Measure | Time frame |
|---|---|
| Biomarkers of oxidative stress both measured after saline and then after ascorbic acid 1. Total antioxidant capacity measured by colorimetric assay 2. Rate of reactive oxygen species generation measured by electron paramagnetic resonance | — |
Countries
United Kingdom
Outcome results
None listed