HIV, musculoskeletal health Infections and Infestations HIV, musculoskeletal health
Conditions
Interventions
The following data will be collected from participants at baseline and follow-up (after one year):
• An interviewer-administered questionnaire
• A standardised musculoskeletal examination including a
Sponsors
Biomedical Research and Training Institute
London School of Hygiene
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 8-16 years (includes pre- and peri-pubertal children) 2. Living in Harare 3. With HIV only if: 3.1 Vertically-acquired HIV and taking ART for at least two years (as adult studies demonstrate ART initiation is followed by an initial decline in BMD which stabilizes after 2 years) 3.2 The child is aware of their HIV status, to avoid inadvertent disclosure as a result of study participation
Exclusion criteria
Exclusion criteria: 1. Acute illness (requiring immediate hospitalisation) and lack of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Total-body less-head (TBLH) Bone Mineral Content (BMC) for lean mass adjusted-for-height (TBLH-BMCLBM) Z-scores) measured using DXA (dual-energy X-ray absorptiometer) at baseline and one year 2. Lumbar spine (LS) Bone Mineral Apparent Density (BMAD) (LS BMAD) Z-score measured using DXA at baseline and one year | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.1 Prevalence of low muscle function; grip strength (Z-score 2 years) explains changes in these bone and muscle outcomes measured using hand x-ray (to measure bone age) and questionnaire (to measure chronological age) at baseline and one year | — |
Countries
Zimbabwe
Outcome results
None listed