Will prophylactic antibiotics in out of hospital cardiac arrest survivors receiving targeted temperature management prevent poor outcomes

A randomized controlled study to evaluate the effect of prophylactic antibiotics in the prevention of early CCU complications in post-cardiac arrest survivors receiving targeted temperature management

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12258520

Enrollment

Registered

2017-02-22

Start date

2017-03-01

Completion date

Unknown

Last updated

2017-10-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Out of hospital cardiac arrest Circulatory System Out of hospital cardiac arrest

Interventions

Participants are randomized 1:1 to one of two groups. Intervention group: Participants receive 3 doses of Ceftriazone every 24 hours. The first dose will be at time of randomization. Control group:

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Age >18 years 2. Out-of-hospital cardiac arrest with ROSC 3. Glasgow coma scale <8 at time of hospital admission 4. Treated with TTM 32-34 degrees Celsius 5. Delay from ROSC to randomization <6 hours 6. Consent from substitute decision maker (SDM)

Exclusion criteria

Exclusion criteria: 1. In hospital cardiac arrest 2. Ongoing antibiotic use for other infection prior to hospitalization (up to 1 week prior) 3. Diagnosis of pneumonia or sepsis prior to hospitalization 4. Non-cardiac illness that is immediate threat to life (i.e. intracranial hemorrhage, perforated viscus etc.). 5. Pregnancy 6. Known anaphylactic reaction to antibiotic used in study

Design outcomes

Primary

Measure	Time frame
1. Incidence of VAP/HAP (within 7 days) is measured using review of patient notes at time of enrollment to 7 days post randomization 2. Incidence of sepsis (within 7 days) is measured using review of patient notes at time of enrollment to 7 days post randomization 3. In-hospital mortality (all cause) is measured using review of patient notes at time of enrollment to day of discharge from hospital	—

Secondary

Measure	Time frame
1. CCU LOS (hours) is measured by reviewing patient notes at the time of admission up to time of discharge from CCU 2. Hospital LOS (days) is measured by reviewing patient notes at time of admission up to time of discharge from hospital 3. Neurologic outcome at time of discharge is measured by categorising patients by cerebral performance category, CPC 1-2 or 3-5 at the time of discharge from hospital 4. Complications of antibiotic use (C. difficile, thrush, other nosocomial infection) is measured by reviewing patient notes during their hospital stay 5. Necessity for re-intubation is measured by reviewing patient notes at the time of admission up to discharge from hospitalization	—

Measure

Time frame

1. CCU LOS (hours) is measured by reviewing patient notes at the time of admission up to time of discharge from CCU 2. Hospital LOS (days) is measured by reviewing patient notes at time of admission up to time of discharge from hospital 3. Neurologic outcome at time of discharge is measured by categorising patients by cerebral performance category, CPC 1-2 or 3-5 at the time of discharge from hospital 4. Complications of antibiotic use (C. difficile, thrush, other nosocomial infection) is measured by reviewing patient notes during their hospital stay 5. Necessity for re-intubation is measured by reviewing patient notes at the time of admission up to discharge from hospitalization

—

Countries

Canada

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026