Schizophrenia Mental and Behavioural Disorders
Conditions
Interventions
Current interventions as of 10/03/2025:
Participants were divided into two groups based on whether they met the criteria for treatment-resistant schizophrenia (TRS). Among the 40 patients with TRS, 8
Sponsors
The Fourth People's Hospital of Wuhu
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed according to the ICD10 (International Classification of Diseases, 10th Revision) criteria for SZ 2. 18 to 65 years old 3. PANSS score was within the range of 70~120
Exclusion criteria
Exclusion criteria: 1. Severe neurological diseases or traumatic brain injury or substance dependence 2. Administration of non-steroidal or steroidal anti-inflammatory drugs within 2 weeks 3. MECT administration 1 month before admission 4. MECT contraindications (including anesthesia allergy, intracranial space-occupying lesions, active pulmonary inflammation, recent myocardial infarction, recent cerebral hemorrhage, retinal detachment, untreated glaucoma, etc) 5. Pregnancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Psychiatric symptoms measured using the Positive and Negative Syndrome Scale (PANSS) at baseline, weeks 2, 4, and 6. | — |
Secondary
| Measure | Time frame |
|---|---|
| Niacin skin flushing response test using 6 different concentrations (triple gradient dilution from 60 mM) of niacin dropped onto the skin at baseline, week 2, 4, and 6 | — |
Countries
China
Contacts
Public ContactSui Bingbing
Outcome results
None listed