Understanding the development of broncho-pulmonary dysplasia (BPD) in preterm infants: mechanisms and different forms of BPD

Pathophysiology phenotypes in infants developing BPD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN12233815

Enrollment

300

Registered

2025-08-19

Start date

2024-01-01

Completion date

Unknown

Last updated

2025-09-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Broncho-pulmonary dysplasia Respiratory

Interventions

Analysis of clinical, imaging physiological and vital data routinely collected during NICU care.

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: Preterm neonates (GA <=30 weeks)

Exclusion criteria

Exclusion criteria: 1. Complex malformations or chromosomal abnormalities 2. Congenital lung anomalies 3. Pneumothorax, pneumomediastinum or pleural effusion 4. Need for surgery 5. Severe hemodynamic instability (defined as any need for inotropes) at any time during the study

Design outcomes

Primary

Measure	Time frame
Gas exchange metrics, lung aeration, vital functions, respiratory support and lung mechanics data are registered at 10, 21 and 28 days of life as well as at 34 and 36 weeks post-conceptional age. Measurements are performed with commonly used techniques such as transcutaneous blood gas monitoring, blood gas analyses, quantitative lung ultrasound, electrical cardiometry, pulsoxymetry and the measurements shown by mechanical ventilators screens, as per clinical routine	—

Measure

Time frame

Gas exchange metrics, lung aeration, vital functions, respiratory support and lung mechanics data are registered at 10, 21 and 28 days of life as well as at 34 and 36 weeks post-conceptional age. Measurements are performed with commonly used techniques such as transcutaneous blood gas monitoring, blood gas analyses, quantitative lung ultrasound, electrical cardiometry, pulsoxymetry and the measurements shown by mechanical ventilators screens, as per clinical routine

—

Secondary

Measure	Time frame
There are no secondary outcome measures	—

Countries

France, Italy, Spain

Contacts

Public ContactAlmudena Alonso-Ojembarrena

almudena.alonso.sspa@juntadeandalucia.es+34956 002 700

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026