The study of bone cells specifically in osteoarthritis and factors affecting progression

Research into sclerostin serum and synovial levels and other factors in osteoarthritis of the knee. An observational study.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN12207865

Enrollment

Registered

2015-06-15

Start date

2013-07-24

Completion date

Unknown

Last updated

2016-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis of the knee and its progression. Musculoskeletal Diseases

Interventions

All patients will have diagnosis of Grade 4 OA and consent to bone and blood samples being taken at time of primary knee arthroplasty. The observations are done pre surgery and serum and synovial flui

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Diagnosis of OA KL Grade 4 2. Primary knee arthroplasty scheduled.

Exclusion criteria

Exclusion criteria: 1. Rheumatoid arthritis 2. Previous joint surgery for OA

Design outcomes

Primary

Measure	Time frame
1. Whether another joint required replacement due to OA 12 months after surgery. Number of days recorded between surgeries if < 12months 2. Are serum sclerostin or synovial sclerostin levels higher in those with progressive OA defined by additional surgery < 12 months from initial surgery. High sclerostin levels in serum and synovial fluid indicate a progressive form of OA	—

Secondary

Measure	Time frame
To identify if any other factors such as Vit D levels and obesity contribute to variable sclerostin levels. Vitamin D levels evaluated pre surgery and 12month postoperatively.	—

Countries

Australia

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026