Heart failure Circulatory System Heart failure
Conditions
Interventions
A total of 80 patients will be recruited to the study:
1. Arm A: impedence cardiography - 40 patients will be assessed using Impedence Cardiography (ICG) to optimise treatment.
2. Arm B: standard card
Sponsors
Good Hope Hospital NHS Trust (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 80 patients who are referred to the cardiology clinic and meet the National Institute for Clinical Excellence (NICE) criteria for biventricular pacemaker implantation will be included in this study. The following inclusion criteria are: 1. Heart Failure 2. Moderate to severe function limitation New York Heart Association (NYHA) class III or IV, or NYHA class II heart failure plus a history of repeated admissions 3. Optimal tolerated treatment with diuretics, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers, beta blockers, spironolactone and digoxin 4. QRS duration (representing the duration of ventricular depolarisation) more than or equal to 120 ms or evidence of mechanical Left Ventricular (LV) dyssynchrony 5. Left ventricular ejection fraction more than or equal to 40%
Exclusion criteria
Exclusion criteria: 1. Contraindications to cardiac pacing 2. Presence of comorbidities likely to threaten survival within 12 months 3. Pulmonary oedema requiring intravenous diuretics in the previous week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective is to assess whether the clinical benefits of cardiac resynchronisation therapy can be optimised using ICG both at the time of pacemaker implantation and during follow up. The primary endpoint is improvement in six minute walking distance. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life using the Minnesota Living with Heart Failure questionnaire. | — |
Countries
United Kingdom
Outcome results
None listed