Endothelial microvascular function Circulatory System Endothelial microvascular function
Conditions
Interventions
Two groups of participants take part in this study, those who are fasting during the Ramadan period and those who are not fasting. Fasting participants complete measurements at baseline (before-fastin
AstraZeneca, London, UK) is applied to the skin surface in order to limit any non-specific vasodilation induced by the electric current. Firstly, we performed Ach and SNP- induced hyperemia by adminis
Moor Instruments Ltd, Axminster, United Kingdom). Ach and SNP solutions are prepared to obtain a final concentration of 2g/dL in deionized water, and 2.5 ml of these solutions was introduced into the
Sponsors
Université libre de Bruxelles (ULB) Erasmus Hospital
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: Fasting participants: 1. Male 2. Older than 18 years 3. Non-smoker 4. No concomitant disease 5. No medications 6. Fasting for Ramadan Non-fasting participants: 1. Male 2. Older than 18 years 3. Non-smoker 4. No concomitant disease 5. No medications 6. Not fasting for Ramadan
Exclusion criteria
Exclusion criteria: 1. Younger than 18 years 2. Smokers 3. Any disease 4. Taking any medication
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of microvascular endothelial function is done at baseline (before-fasting session), fasting session (during Ramadan fasting period), post-fasting session (34 days after the end of Ramadan) for the fasting participants, and baseline and 28 days for non-fasting participants. Evaluation of Microvascular endothelial function include: 1. Endothelial-dependent and independent vasodilations, evaluated by assessing skin hyperemia response to Ach and SNP 2. Nitric oxide bioavailability, measured by assessing skin hyperemia response to local heating | — |
Secondary
| Measure | Time frame |
|---|---|
| All measures are taken at baseline (before-fasting session), fasting session (during Ramadan fasting period), post-fasting session (34 days after the end of Ramadan) for the fasting participants, and baseline and 28 days for non-fasting participants. 1. Blood pressure is measured using an automated sphygmomanometer (WelchAllyn, USA), in the sitting position 2. Weight is measured using a classic balance 3. Haematological parameters (fasting blood glucose, triglycerides, total cholesterol, high-density lipoprotein, low-density lipoprotein, blood urea nitrogen, creatinine, hepatic enzymes and total bilirubin) are measured using blood testing | — |
Countries
Belgium
Outcome results
None listed