Specialty: Primary Care, Primary sub-specialty: Respiratory disorders
Conditions
Interventions
Eligible participants will receive a letter from their GP inviting them to take part in the study, and return a reply form to the study team. They will have four appointments, at which details of thei
Sponsors
University of Oxford
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participant is willing and able to give informed consent for participation in the study 2. Male or Female, aged 40 years or above 3. Have a diagnosis of COPD meeting spirometric criteria for diagnosis of COPD (FEV1/FVC ratio <0.7) as recorded in their primary care records
Exclusion criteria
Exclusion criteria: 1. Any previous diagnosis of bronchiectasis, cystic fibrosis, interstitial lung disease, lung cancer, alpha-1 anti-trypsin deficiency or other chronic respiratory disease not related to COPD or asthma 2. Co-existent active diagnosis of asthma (reviewed in the last 2 years) 3. Currently prescribed an ICS, or had a prescription for ICS in the last 2 years 4. Regularly takes oral steroids, or has been regularly taking oral steroids in the last 2 years. Regular use of oral steroids will in general be defined as a longer than 2 week course, although discrete short courses with tapering are acceptable for inclusion. 5. Prior inclusion in a clinical trial of an investigational medicinal product for airways disease in the last 90 days or which may involve administration of oral or inhaled steroid treatment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Biomarker levels (eosinophils, FeNO, CRP, periostin) are measured at baseline, 2, 4 and 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Diagnostic accuracy of near-patient eosinophils compared to laboratory eosinophils is assessed using fingerprick blood test at baseline, 2, 4 and 6 months 2. Feasibility of undertaking such measurements in a primary care setting is assessed using surveys created for the purpose of this study at 6 months | — |
Countries
United Kingdom
Contacts
Public ContactHelen Ashdown
Outcome results
None listed