Cardiovascular injury (primary inflammatory, ischaemic, or secondary to systemic pathophysiology) in the context of COVID-19 infection Circulatory System Cardiovascular disease, COVID-19 (SARS-CoV-2 infection)
Conditions
Interventions
Participants with confirmed COVID-19 will undergo biomarker analysis, using Troponin, Brain Natriuretic Peptide (BNP), and C-Reactive Protein (CRP) to assess for evidence of cardiovascular injury.
Sponsors
The Aga Khan University Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. COVID19 positive test within the previous 2 weeks (can be extended to 4 weeks at the investigator's discretion) 2. Aged =18 years
Exclusion criteria
Exclusion criteria: 1. Prior diagnosis of myocardial infarction 2. Requiring invasive or non-invasive ventilation 3. Previous coronary revascularisation or cardiac surgery 4. Unable to undergo CT or CMR scanning, due to severe renal failure (estimated glomerular filtration rate <30 ml/min) or major allergy to iodinated contrast media /gadolinium 5. Pregnancy or breast feeding 6. Unable to give informed consent 7. Contraindication to imaging example metal fragments in the eye
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of COVID-19 patients with evidence of cardiovascular injury measured using CT, CMR, or FDG-PET scan within 2 weeks of admission | — |
Secondary
| Measure | Time frame |
|---|---|
| Explore mechanisms of cardiovascular injury associated with COVID-19 measured using CT, CMR, or FDG-PET scan within 2 weeks of admission | — |
Countries
Kenya
Outcome results
None listed