Severe generalised chronic periodontitis (generalised stages III-IV, grades B-C periodontitis) Oral Health Chronic periodontitis
Conditions
Interventions
Participants are randomly assigned to treatment groups in ascending order, at the time of surgery, according to a balanced distribution system (random block design, block size = 6).
1.
CAL, calculated as the sum/rest of PD and REC
bleeding on probing (BOP), assessed dichotomously. Plaque index (PlI) is also assessed. In each quadrant, the most accessible location with the deepest PD and BOP is selected. Subgingival plaque sampl
Sponsors
Pontificia Universidad Católica Madre y Maestra
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Severe generalized chronic periodontitis (Armitage, 1999), corresponding to generalized stage III-IV periodontitis, with grades B-C (Caton et al., 2018; Papapanou et al., 2018; Tonetti, Greenwell, & Kornman, 2018) 2. A least 10 teeth in function, excluding third molars 3. Sites with PD> 5 mm, in =2 teeth in =1 quadrant 4. Radiographic evidence of bone loss =30% in, at least, 30% of the dentition 5. Older than 18 years
Exclusion criteria
Exclusion criteria: 1. Pregnant or breastfeeding women 2. Systemic diseases and/or chronic medications that may affect the periodontal status and /or requiring antibiotic prophylaxis 3. Having received systemic antimicrobial treatment in the previous 3 months 4. Have received periodontal treatment in the 6 months prior to the start of the study 5. Allergic to metronidazole, or to any of the components of their commercial formulations (Metrex 500 mg®, Laboratorio Union SRL, Santo Domingo, República Dominicana) 6. Refuse to sign the informed consent 7. Smokers =10 cigarettes/day
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probing Depth (PD), measured using a UNC-15 mm periodontal probe (Hu-Friedy, Leinmen, Germany) at baseline and 12-month visit | — |
Secondary
| Measure | Time frame |
|---|---|
| At baseline, 3 months after the last surgery session, and then after 6 and 12 months: 1. Probing Depth distribution [/overgrowth (measured to the nearest millimeter), Clinical Attachment Loss (calculated as the sum/rest of PD and REC) and open pockets measured using a UNC-15 mm periodontal probe (Hu-Friedy, Leinmen, Germany) 2. Plaque Index recorded using the O'Leary Index 3. Bleeding on Probing measured using a dichotomous analysis (presence or absence) 4. Microbiological variables (frequency of detection and counts of each targeted bacteria) samples analysed by multiplex quantitative polymerase chain reaction (qPCR), at baseline and after 12 months following surgical therapy | — |
Countries
Dominican Republic
Outcome results
None listed