Patients that undergo elective pancreatoduodenectomy for a malignant or premalignant periampullary lesion Cancer
Conditions
Interventions
Participants will be randomised to one of two treatment arms:
1. Axial slicing according to Verbeke: Parallel margins (en face) from the pancreatic neck margin, proximal distal bile du
Sponsors
Amsterdam UMC, location AMC
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All patients that undergo pancreatoduodenectomy
Exclusion criteria
Exclusion criteria: 1. Pancreatoduodenectomy performed for chronic pancreatitis 2. Pancreatoduodenectomy preoperatively confirmed neuro-endocrine tumors and hamoudi / acinar cell tumors 3. Pancreatoduodenectomy performed for tumors outside the periampullary region
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Level of certainty in determining the primary origin of the tumor by 4 pathologists. Pathologists assess the macroscopic photos of each specimen and score how certain they are of the primary origin of the tumor (0-100%) in a survey. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Inter-observer agreement (kappa) among different pathologists in origin of the tumor (by survey) 2) R1 rate for pancreatic and periampullary cancers/lymph node harvest Both determined during routine pathological examination. | — |
Countries
Netherlands
Outcome results
None listed