We all eat microbes: diet as reservoir of microorganisms that preserve the ecosystem services of the human gastrointestinal microbiota (the µbEat project)

Evaluation of the effect of diet-associated microorganisms on the gut microbiome, blood metabolome, immune system, and metabolic status in healthy adult subjects: a randomized controlled crossover dietary intervention (µbEat-trial)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN12131144

Enrollment

Registered

2026-01-26

Start date

2024-09-09

Completion date

Unknown

Last updated

2026-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of low-grade chronic systemic inflammation and related non-communicable disease risk through modulation of the gut microbiome, immune function, and metabolic status in healthy adult subjects. Digestive System

Interventions

Two dietary interventions: 1. Low microbial diet (LM): diet designed to minimize ingestion of live food-associated microorganisms. 2. Microbe-enriched diet (MR): diet allowing and promoting ingestion

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Healthy adult subjects, without diagnosed acute or chronic diseases 2. Age between 18 and 60 years 3. Ability to provide written informed consent 4. Willingness and ability to comply with the dietary intervention, sample collection (feces, blood, saliva), and study procedures.

Exclusion criteria

Exclusion criteria: 1. Use of antibiotics within 1 month prior to study start 2. Use of antacids or gastrointestinal prokinetic drugs 3. Chronic inflammatory bowel diseases 4. Active irritable bowel syndrome (IBS) 5. Viral or bacterial enteritis within 2 months prior to enrollment 6. History of gastric or duodenal ulcers within the previous 5 years 7. Any severe disease that could interfere with the dietary intervention or study outcomes 8. Pregnancy or breastfeeding 9. Recent history or suspicion of alcohol or drug abuse 10. Poor reliability or conditions affecting compliance/adherence to the study protocol 11. Previous participation in this study

Countries

Italy

Contacts

Public ContactSimone Guglielmetti

simone.guglielmetti@unimib.it0264483343

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 15, 2026