Centrally mediated pain after injury to the knee: A study of pain and function after knee fracture

Centrally mediated pain following injury to the knee: a Cross-sectional study of pain and function following intra-articular knee injury

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN12097923

Enrollment

Registered

2024-07-11

Start date

2024-08-01

Completion date

Unknown

Last updated

2024-07-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevalence of centrally mediated pain after intraarticular knee trauma Musculoskeletal Diseases

Interventions

Participants will be located from a database of trauma and will complete initial questionnaires remotely with a proportion being purposively sampled. These sampled participants will be assessed with f

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Adult participants who attended Nottingham University Hospitals under the care of orthopaedic trauma and underwent treatment for intraarticular knee injuries from 2015-2023. 2. Must include one or more of the injury groups outlined below and include an intraarticular component as defined in AO Classification (2018) (1): 2.1. Patella fracture 2.2. Tibial plateau fracture 2.3. Distal femur fracture 3. Able to give informed consent. 4. Able to complete required questionnaires.

Exclusion criteria

Exclusion criteria: 1. Aged 17 years or under 2. Concomitant fracture involving another joint 3. Intra articular knee fracture that involves preceding prosthesis or implant. 4. Active malignancy 5. Pregnancy or breast feeding 6. People in custody of the police or incarcerated persons 7. Inability to read or write English.

Design outcomes

Primary

Measure	Time frame
Measured at a single time point: 1. Features of centrally mediated pain measured using quantitative sensory testing (conditioned pain modulation, pressure algometry) 2. Central Aspects of Pain in the Knee Questionnaire (CAP-Knee) 3. Measures of Central sensitisation and neuropathic pain (Central sensitisation inventory (CSI), PainDETECT questionnaires) 4. Numerical Rating Scale (NRS) 5. Brief pain inventory (BPI)	—

Measure

Time frame

Measured at a single time point: 1. Features of centrally mediated pain measured using quantitative sensory testing (conditioned pain modulation, pressure algometry) 2. Central Aspects of Pain in the Knee Questionnaire (CAP-Knee) 3. Measures of Central sensitisation and neuropathic pain (Central sensitisation inventory (CSI), PainDETECT questionnaires) 4. Numerical Rating Scale (NRS) 5. Brief pain inventory (BPI)

—

Secondary

Measure	Time frame
Measured at a single time point: 1. Features of psychological distress measured using Hospital anxiety and depression scale (HADS) 2. Knee Function after trauma, measured using the The Knee Injury and Osteoarthritis Outcome Score (KOOS) and EQ-5D-5L	—

Countries

England, United Kingdom

Contacts

Public ContactChris Busby

christopher.busby@nhs.net+44 115 924 9924

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026