People over 65 years, healthy (self-report), and living independently or in a community residence Not Applicable
Conditions
Interventions
Participants are randomized into two groups with different nutritional supplementation:
1. Intervention group: This group will take 13.5 ml of omega-3 fatty acid supplementation daily for 26 weeks at
Sponsors
Swiss Federal Institute of Technology Zurich (ETH) (Switzerland)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age above 65 years 2. Live independently or in a residency dwelling 3. Non-smoker 4. Healthy (self-reported)
Exclusion criteria
Exclusion criteria: 1. Mobility or cognitive impairments 2. Orthopaedic or neurological diseases preventing training participation 3. Rapidly progressive or terminal illness, acute or chronic illness 4. History of stroke, epilepsy, or seizure 5. Medication that interacts with nutritional supplementation 6. Medication that acts on a neuronal level 7. Mini Mental Status < 22 points 8. Signs of upcoming depression (GDS) 9. Electronic or metallic head implants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Current primary outcome measures as of 24/02/2016: 1. Structural level: 1.1. Transcranial magnetic stimulation: Motor evoked potential in M.tibialis anterior 2. Functional level: 2.1. Electroencephalography: Event related potential and frequency band distribution 2.2. Cognitive test: Test for Attentional Performance (TAP) All measures are assessed pre-intervention and after intervention. Previous primary outcome measures: 1. Structural level: 1.1. Transcranial magnetic stimulation: Motor evoked potential in M.tibialis anterior 2. Functional level: 2.1. Electroencephalography: Event related potential and frequency band distribution 2.2. Cognitive tests: Test for Attentional Performance (TAP) and Attention Network Test (ANT) All measures are assessed pre-intervention and after intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Gait parameters: 1.1. Temporal and spatial gait parameters are assessed with the Physilog® 2. Prevention of falls: 2.1. Icon Falls Efficacy Scale International (Icon-FES-I) questionnaire is used as a measure of 'concern' about falling, to determine the transfer effects of training to activities of daily living 3. Mental state and depression: 3.1. Mini Mental State Examination (MMSE) 3.2. Geriatric Depression Scale (GDS): symptoms of depression are recorded. The German version of the GDS has a good validity and reliability 4. Blood samples measuring fatty acid All measures are assessed pre-intervention and after intervention. In addition, blood samples are measured after 16 weeks. | — |
Countries
Switzerland
Outcome results
None listed