Type 1 diabetes Nutritional, Metabolic, Endocrine Insulin-dependent diabetes mellitus
Conditions
Interventions
The study population will be drawn from the diabetes population attending the diabetes clinic at Raigmore Hospital in Inverness. Forty eight people with type 1 diabetes > 5 years will be recruited. 5
Sponsors
University of the Highlands and Islands (UK)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with type 1 diabetes 2. Group A: patients not on insulin pump therapy and not on statin n=12 3. Group B: patients not on insulin pump therapy, but on statin n=12 4. Group C: patients on insulin pump therapy > 6 months and not on a statin n=12 5. Group D: patients on insulin pump therapy > 6 months and on a statin n=12
Exclusion criteria
Exclusion criteria: 1. Type 2 diabetes 2. Very poor glucose control (HbA1c > 84 mmol/mol (10%) 3. Renal impairment (eGFR < 60ml/min/kg) 4. Recently diagnosed patients (<5 years) 5. Smokers or recently stopped (<6 months) ex-smokers 6. Chronic inflammatory disease (e.g. rheumatoid arthritis, Inflammatory bowel disease, asthma, chronic obstructive pulmonary disease)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To determine if insulin pump therapy reduces oxidative stress, endothelial dysfunction and platelet-monocyte conjugation in patients with type 1 diabetes | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine if insulin pump therapy + statins have a synergistic effect in terms of reducing oxidative stress, endothelial dysfunction and platelet-monocyte conjugation in patients with type 1 diabetes | — |
Countries
United Kingdom
Contacts
Public ContactSandra MacRury
Outcome results
None listed