Adult food allergy Not Applicable
Conditions
Interventions
PAFA-Stage 2 follows on from PAFA-Stage 1 community survey where people in the general population aged 18-70 years living in Manchester, Southampton or the Isle of Wight were asked if they experienced
Sponsors
Manchester University NHS Foundation Trust
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All must be respondents to the PAFA-Stage 1 community survey and consent to be invited to take part in PAFA-Stage 2 2. Cases will be identified as participants who responded to the PAFA-Stage 1 and indicated they have a self-reported adverse reaction to food which is consistent with it being a possible food allergy 3. Controls will be identified as participants who responded to the PAFA-Stage 1 and indicated they do not have a self-reported adverse reaction to food 4. Both cases and controls will be capable of giving informed consent
Exclusion criteria
Exclusion criteria: Adults who have dementia, Alzheimer’s disease, or are receiving palliative care
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probable IgE-mediated food allergy, which is defined as all of: 1. Self-reported symptoms associated with consumption of a particular food which are typical of an IgE-mediated food allergy (see list below) [administered questionnaire] 2. Symptoms onset within 2 hours of contact with food [administered questionnaire] 3. Evidence of sensitization to the same food in the form of a positive skin prick test (SPT; =3 mm wheal) and/or positive serum specific IgE (=0.35 kU/L) and/or positive serum specific IgE to component associated with clinical allergy (=0.35 kU/L) to the same food. Symptoms considered to be typical of IgE-mediated food allergy include any of the following: itching or tingling in the mouth, lips, ears or throat; swelling of the eyes, lips, or mouth; nettle sting like rash or itchy skin, or red rash; diarrhoea (other than food poisoning); vomiting (other than food poisoning); stomach cramps; hoarseness or swelling of throat; a runny, stuffy nose, or sneezing; red, sore, or running eyes; cough, wheeze, chest tightness, or breathlessness; fainting or dizziness. Timepoint: December 2022 | — |
Secondary
| Measure | Time frame |
|---|---|
| Probable non-IgE mediated adverse reaction to food, which is defined as all of: 1. Self-reported symptoms associated with consumption of a particular food which are typical of a non-IgE-mediated adverse reaction to food (see below) [administered questionnaire] 2. Symptoms after 2 hours of consumption [administered questionnaire] 3. No evidence of sensitisation to food in the form of a negative skin prick test (SPT; <3 mm wheal) and/or negative serum specific IgE (<0.35 kU/L) to the same food. Symptoms typical of non-IgE mediated adverse reaction to food include any of the following: difficulty swallowing; regurgitating stomach contents (stomach contents raising back to the oesophagus or mouth); reflux/ heartburn/indigestion; fainting or dizziness; headaches; stomach cramps; diarrhoea (other than food poisoning); vomiting (other than food poisoning); constipation; other digestive problems (e.g. bloating, wind) Timepoint: December 2022 | — |
Countries
Netherlands, United Kingdom
Outcome results
None listed