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Exploring antibiotic prescribing in acute respiratory infection

Exploring factors associated with antimicrobial prescribing in adults with acute respiratory infection (ARI) amongst UK secondary care prescribers and the potential utility of host response testing to improve use: a questionnaire-based survey

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ISRCTN
Registry ID
ISRCTN11955241
Enrollment
200
Registered
2025-07-10
Start date
2025-07-02
Completion date
Unknown
Last updated
2026-07-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute respiratory infection, antibiotic prescribing Infections and Infestations

Interventions

This study aims to explore factors associated with antibiotic prescribing by secondary care prescribers in adult patients with acute respiratory illness (ARI), in whom viruses are detected. Also, to i

Sponsors

University Hospital Southampton NHS Foundation Trust
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: Qualified prescribing Medical Doctor, Nurse practitioner or Advanced Care Practitioner, working within secondary care in the NHS, whose primary patients are =18 years of age 1. Participants must regularly assess patients presenting to the hospital with ARI 2. Participants must work in the following specialities: Emergency medicine, Acute medicine, Respiratory medicine, Geriatric medicine, Infectious diseases, General medicine

Exclusion criteria

Exclusion criteria: Not meeting the inclusion criteria

Design outcomes

Primary

MeasureTime frame
Factors associated with antibiotic use in adults presenting to the ED with ARI where viruses are detected will be measured using data collected during focus groups and from questionnaires. The factors will be described and ranked. The detailed reasons underpinning these factors will be explored through thematic analysis.

Secondary

MeasureTime frame
1. A list of the desirable characteristics of a new theoretical host response diagnostic test will be described and ranked, measured using data collected during focus groups and from questionnaires. Additionally, the detailed reasons underpinning these factors will be explored through thematic analysis. 2. The impact on antibiotic use of a theoretical host response test in adults presenting to hospitals with ARI, who have tested positive for viral respiratory pathogens, will be described using data collected from a questionnaire containing case vignettes covering a range of clinical scenarios. The detailed reasons underpinning any change in prescribing behaviours following host-response testing being available will be identified using thematic analysis.

Countries

England, United Kingdom

Contacts

Public ContactAlex Tanner
at1g20@soton.ac.uk+44 (0)2381206325

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jul 23, 2026