HEART-GP: developing a quick way to check for heart issues in primary care

HEART-GP: developing a rapid rule-out strategy for acute cardiac conditions in patients with acute-onset chest pain in out-of-hours primary care

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ISRCTN

Registry ID

ISRCTN11954040

Enrollment

900

Registered

2023-10-20

Start date

2023-03-17

Completion date

Unknown

Last updated

2026-03-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute chest pain Signs and Symptoms

Interventions

This is a diagnostic accuracy study with a qualitative element that will gather data using interviews and focus group meetings with GPs. GPs will be asked to fill out a digital questionnaire containin

Eligibility

Sex/Gender

All

Age

18 Years to 100 Years

Inclusion criteria

Inclusion criteria: All participants must meet all of the following criteria: Aged 18 years or older Patients: Presence of chest pain at the time of consultation (with a duration of at least 15 minutes) where a cardiac etiology is considered possible

Exclusion criteria

Exclusion criteria: Patients: 1. Hemodynamic instability 2. Chest trauma preceding chest pain 3. Not able to provide informed consent 4. Not registered with a GP in the Netherlands

Design outcomes

Primary

Measure	Time frame
Diagnostic test characteristics (sensitivity, specificity, accuracy, LR+, LR-, NPV and PPV) for the occurrence of major adverse cardiovascular events (MACE) measured using medical record data (primary care and/or hospital records) within 6 weeks of the index consultation	—

Secondary

Measure	Time frame
1. Test characteristics measured using sensitivity, specificity, accuracy, LR+, LR-, NPV and PPV using a more restricted definition of acute coronary syndrome within 6 weeks of the index consultation 2. End-user involvement will be measured using interviews with GPs and triage nurses who participated in the study to evaluate their experiences with the troponin and risk stratification tools, and enrolled patients who will be asked to reflect on the point-of-care-test and the risk scores and how the physician discussed these with them, as well as on the flow-of-care and satisfaction by the end of recruitment 3. Study evaluation measured using interviews with GPs and triage nurses who participated in the study to evaluate their experiences with the troponin and risk stratification tools, and enrolled patients who will be asked to reflect on the point-of-care-test and the risk scores and how the physician discussed these with them, as well as on the flow-of-care and satisfaction by the end of the overall study	—

Measure

Time frame

1. Test characteristics measured using sensitivity, specificity, accuracy, LR+, LR-, NPV and PPV using a more restricted definition of acute coronary syndrome within 6 weeks of the index consultation 2. End-user involvement will be measured using interviews with GPs and triage nurses who participated in the study to evaluate their experiences with the troponin and risk stratification tools, and enrolled patients who will be asked to reflect on the point-of-care-test and the risk scores and how the physician discussed these with them, as well as on the flow-of-care and satisfaction by the end of recruitment 3. Study evaluation measured using interviews with GPs and triage nurses who participated in the study to evaluate their experiences with the troponin and risk stratification tools, and enrolled patients who will be asked to reflect on the point-of-care-test and the risk scores and how the physician discussed these with them, as well as on the flow-of-care and satisfaction by the end of the overall study

—

Countries

Netherlands

Contacts

Public ContactRalf Harskamp

heartgp@amsterdamumc.nl+31-20-5669111

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Mar 20, 2026