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Can images of the eyes be used to develop a reliable, non-invasive method for categorising the severity of jaundice?

Mechanised measurement of icterus from sclera tinge yellowness in hospital patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN11941403
Enrollment
100
Registered
2026-05-29
Start date
2026-03-18
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Symptoms and signs involving the digestive system and abdomen Signs and Symptoms

Interventions

Participants will be adult in-patients with blood bilirubin measurements available from routine blood tests taken as part of their standard care. Their initial location of treatment will include the E

Sponsors

University of York
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: 1. Willing and able to give informed consent for participation in the study 2. Male, female, or other, aged 18 years and above 3. Able, in the investigator’s opinion, and willing to comply with all study requirements 4. Can be feasibly consented and measured within 48 hours of their blood test 5. Can be either mobile or immobile but must be capable of opening their eyes for the photograph 6. Currently admitted to the hospital as an inpatient 7. Deemed suitable to approach by the clinical ward team

Exclusion criteria

Exclusion criteria: 1. Intoxicated or under the undue influence of drugs or medications 2. Advanced eye pathology, as determined by the patient or clinician 3. Periorbital or orbital cellulitis 4. Implantable or non-removable contact lenses 5. Inability to obtain a scleral photographic image within 48 hours of the blood test 6. Epilepsy 7. Cataracts

Design outcomes

Secondary

MeasureTime frame
There are no secondary outcomes

Countries

England, United Kingdom

Contacts

Public ContactGeorgia Sowerby
georgia.sowerby@york.ac.uk+44 (0)1904 325501

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Jun 11, 2026