Oesophageal cancer, colorectal cancer, Crohn's disease Cancer
Conditions
Interventions
A ‘symptom and risk factor’ questionnaire will be developed based on known symptoms and risk factors for the disease being studied. Saliva will be collected from patients from the identified groups re
Sponsors
University College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Current participant inclusion criteria as of 25/08/2021: For the initial study of oesophageal disease, both current and new patients identified as having oesophageal disease (e.g. Barrett’s oesophagus, oesophageal cancer) will be recruited together with those being referred along the 2-week-wait cancer-target pathway. Patients without oesophageal disease attending for a clinically indicated endoscopy may be recruited as controls. For the initial study of colorectal disease, patients will be recruited from the National Bowel Cancer Screening Programme, as well as from other patients with colorectal disease attending for colonoscopy. Patients without colorectal disease attending for a clinically indicated colonoscopy may be recruited as controls. For patients with Crohn's disease, both the UK IBD Bioresource and participating centres will contact patients inviting them to sign up for the study online. Previous participant inclusion criteria: For the initial study of oesophageal disease, both current and new patients identified as having oesophageal disease (e.g. Barrett’s oesophagus, oesophageal cancer) will be recruited together with those being referred along the 2-week-wait cancer-target pathway. Patients without oesophageal disease attending for a clinically indicated endoscopy may be recruited as controls. For the initial study of colorectal disease, patients will be recruited from the National Bowel Cancer Screening Programme, as well as from other patients with colorectal disease attending for colonoscopy. Patients without colorectal disease attending for a clinically indicated colonoscopy may be recruited as controls.
Exclusion criteria
Exclusion criteria: Current participant exclusion criteria as of 25/08/2021: 1. Patients who are unable to undergo definitive investigations such as colonoscopy or surgery as a definitive pathological diagnosis will not be achievable in such instances 2. Patients who are unable to give informed consent in English, or in the presence of an English translator 3. Pregnant women 4. Patients under the age of 18 years Previous participant exclusion criteria: 1. Patients who are unable to undergo definitive investigations such as colonoscopy or surgery as a definitive pathological diagnosis will not be achievable in such instances 2. Patients who are unable to give informed consent in English, or in the presence of an English translator 3. Pregnant women 4. Patients under the age of 21 years
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Epigenetic and transcriptomic biomarkers, measured using next generation sequencing of saliva/blood/tissue samples collected at single study visit | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease symptoms and risk factors, measured using questionnaire at single study visit | — |
Countries
England, United Kingdom
Outcome results
None listed