Comparison of dexmedetomidine and ketamine on pain after total knee arthroplasty

Comparing the effects of intraoperative dexmedetomidine and ketamine on postoperative pain in total knee arthroplasty: a randomized trial

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11906298

Enrollment

104

Registered

2025-06-13

Start date

2023-07-01

Completion date

Unknown

Last updated

2026-01-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Total knee arthroplasty Surgery

Interventions

Patients were randomly allocated into two groups (1:1 ratio) using a computer-generated randomisation list created by an independent biostatistician before patient enrolment. Block randomisation was n

Eligibility

Sex/Gender

All

Age

18 Years to 110 Years

Inclusion criteria

Inclusion criteria: 1. Adult patients aged =18 years 2. Scheduled for elective unilateral primary total knee arthroplasty under spinal anesthesia 3. American Society of Anesthesiologists (ASA) physical status I–III 4. Provided written informed consent

Exclusion criteria

Exclusion criteria: 1. Body mass index (BMI) >35 kg/m² 2. Uncontrolled hypertension 3. Renal or hepatic disease 4. Mental, psychiatric or neuromuscular disorders 5. Known allergies or contraindications to dexmedetomidine, ketamine, or local anesthetics 6. Contraindications to spinal anesthesia 7. Refusal to participate in the study

Design outcomes

Primary

Measure	Time frame
Total opioid consumption (in milligrams of tramadol) is measured using data obtained from the intravenous PCA device at 24 hours postoperatively.	—

Secondary

Measure	Time frame
1. Pain intensity is measured using the Visual Analogue Scale (VAS) (0 = no pain, 10 = worst pain) in both sitting and supine positions at 0, 4, 8, 12, 18, and 24 hours postoperatively 2. Need for rescue analgesia is determined based on VAS =4, and the administration of IV meperidine (0.3 mg/kg) is recorded during the first 24 hours 3. Hemodynamic parameters including heart rate, systolic, diastolic, and mean arterial pressure are measured using noninvasive monitoring at 0, 4, 8, 12, 18, and 24 hours postoperatively 4. Ambulation time (in hours) is recorded based on the time to first mobilization after surgery 5. Side effects including postoperative nausea and vomiting, hypotension, and bradycardia are documented based on clinical observation and medication use within the first 24 hours 6. Patient satisfaction is measured using a four-point scale (0 = poor, 1 = moderate, 2 = good, 3 = excellent) at 24 hours postoperatively	—

Measure

Time frame

1. Pain intensity is measured using the Visual Analogue Scale (VAS) (0 = no pain, 10 = worst pain) in both sitting and supine positions at 0, 4, 8, 12, 18, and 24 hours postoperatively 2. Need for rescue analgesia is determined based on VAS =4, and the administration of IV meperidine (0.3 mg/kg) is recorded during the first 24 hours 3. Hemodynamic parameters including heart rate, systolic, diastolic, and mean arterial pressure are measured using noninvasive monitoring at 0, 4, 8, 12, 18, and 24 hours postoperatively 4. Ambulation time (in hours) is recorded based on the time to first mobilization after surgery 5. Side effects including postoperative nausea and vomiting, hypotension, and bradycardia are documented based on clinical observation and medication use within the first 24 hours 6. Patient satisfaction is measured using a four-point scale (0 = poor, 1 = moderate, 2 = good, 3 = excellent) at 24 hours postoperatively

—

Countries

Türkiye

Contacts

Public ContactSenem Urfali

senemurfali@gmail.com+90 (0)5326331797

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026