First episode psychosis Mental and Behavioural Disorders Unspecified nonorganic psychosis
Conditions
Interventions
Experimental intervention: extended specialised early intervention service (SEI) -
Patients randomised to the experimental condition will receive an extension of the SEI service beyond
Sponsors
Douglas Hospital Research Centre (Canada)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: The aim of our study is to demonstrate effectiveness of a model of care applicable to the largest number of persons with first episode psychosis (FEP) as they appear in clinical settings and not to show efficacy of a single treatment intervention for patients with pure unencumbered diagnoses. Therefore, the inclusion criteria are designed to recruit patients truly representative of FEP patients likely to be seen in any treatment facility: 1. Aged 18 - 35 years, either sex 2. Able to provide informed consent 3. Meeting Diagnostic and Statistical Manual of Mental Disorders, 4th Edition (DSM-IV) criteria for a psychotic disorder (schizophrenia spectrum psychoses and affective psychosis) confirmed by the Structured Clinical Interview for DSM-IV Axis I disorders Patient Edition 4. Have completed 24 months of treatment and follow-up in one of the two SEI services. Patients with co-morbid diagnosis of substance abuse and dependence will be included.
Exclusion criteria
Exclusion criteria: 1. Lack of ability to provide informed consent as assessed by requesting patient to provide brief summary of treatment protocol following presentation of the consent form 2. Lack of ability to speak either English or French fluently as assessed by the patient indicating English or French as the preferred language for communication 3. Intelligence quotient (I.Q.) below 70 as assessed using the Wechsler Adult Intelligence Scale (WAIS) short form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Defined by remission status, measured as the proportion of patients in complete remission (to make it comparable to the OPUS follow-up study in order to increase generalisability) achieved by patients for the entire period of three years of the additional intervention (following randomisation). Using sustained remission as the primary outcome measure is justified because of high association of length of remission and functional outcome (work and social functioning). Remission status will be measured upon entry and every three months (at evaluation) until completion at 3 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical outcome, measured upon entry and every three months until completion 2. Functional outcome, measured every six months until completion 3. Quality of life, measured every six months until completion | — |
Countries
Canada
Outcome results
None listed