Sentence processing impairments in post-stroke aphasia Mental and Behavioural Disorders
Conditions
Interventions
After first baseline assessment, participants are randomised with a 1:1 ratio to Immediate or Deferred treatment conditions. Randomisation is stratified by sex and employs block randomisation. Researc
Task 2: an auditory word monitoring paradigm
Task 3: sentence production with a gradual increase in sentence length and creativity with feedback given using automatic speech recognition. All stimuli include high-frequency phrase/sentence frames.
Sponsors
University College London
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged over 18 years 2. Pre-morbid competence in English and frequent use of English post-stroke 3. Pre-morbidly right-handed with left-sided stroke; or pre-morbidly left-handed with right-sided stroke 4. At least 4 months post-onset of stroke which resulted in aphasia 5. Presence of moderate to severe aphasia, characterised by spoken sentence comprehension impairment (scoring <16 blocks correct on TROG-2) and/or spoken sentence production difficulties (incomplete and/or simple sentences) at baseline assessment 6. Capacity to give informed consent 7. Sufficient auditory and visual capacity to interact with the therapy app
Exclusion criteria
Exclusion criteria: 1. Significant other neurological disorder (e.g. neurodegenerative illness) 2. History of speech and language disorder prior to stroke (e.g. developmental language disorder) 3. Concurrent involvement in another therapy study 4. Previous involvement in the UTILISE-1 therapy study 5. Severe apraxia of speech: unable to repeat high-frequency single words and short sentences
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Sentence comprehension measured using a count for total items correct on the Test for Reception of Grammar (TROG-2) at two baseline timepoints and two outcome timepoints 2. Fluency and connectivity of speech measured in narrative samples by automated language analysis (FLAT) via combination ratio (number of three-word combinations/total number of words) at two baseline timepoints and two outcome timepoints | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Retrieval and grammaticality of treated and matched control sentences measured using a study-specific story completion test at Baseline 2 and immediately after the intervention 2. Quality of life measured by score on the Communication Outcomes After Stroke at Baseline 1 and immediately post-treatment 3. Sentence production in narrative speech profiled with other FLAT variables (mean length of utterance, function word ratio and frequency of words and their combinations) at two baseline timepoints and two outcome timepoints 4. Overall aphasia severity measured by scores on the Quick Aphasia Battery at second baseline and immediate and maintenance outcome timepoints | — |
Countries
England, United Kingdom
Outcome results
None listed