Fever Signs and Symptoms Fever
Conditions
Interventions
Group 1: A single dose of oral acetaminophen (15 mg/kg) plus placebo rectal suppository (size equivalent to a 35 mg/kg rectal acetaminophen suppository)
Group 2: A single dose of oral placebo (equival
Sponsors
American University of Beirut (Lebanon)
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age between 6 months and 13 years 2. Rectal temperature greater than or equal to 38.5 °C 3. Consent of treating physician 4. Written consent of parent and oral consent of child if older than 10 years 5. No antipyretic intake for 8 hours prior to enrolment
Exclusion criteria
Exclusion criteria: 1. Presence of concurrent or previous hepatic disease 2. Chronic and/or serious disease such as malignancy, septic shock, malabsorption syndromes etc. 3. Any condition interfering with the absorption of oral or rectal acetaminophen such as vomiting or severe diarrhoea, ileus, rectal bleeding etc. 4. Hypersensitivity to acetaminophen
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to maximum antipyresis following administration of a single dose of acetaminophen. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes included the temperatures at one, two, three, four, five, and six hours from administration and possible side effects such as hypothermia. | — |
Countries
Lebanon
Outcome results
None listed