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Does adding an oral cortisone pill to the regular treatment of patients with rib cage pain and swelling improve their pain and quality of life?

The efficacy of oral corticosteroids for treatment of Tietze syndrome: a pragmatic randomized controlled trial

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
ISRCTN
Registry ID
ISRCTN11877533
Enrollment
40
Registered
2022-04-30
Start date
2020-08-01
Completion date
Unknown
Last updated
2023-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Teitze syndrome: costochondritis of the chest wall with joint swelling Skin and Connective Tissue Diseases

Interventions

The intervention group will have oral corticosteroid therapy for a short period in addition to all conventional methods of treatment. The control group will have only the conventional

Sponsors

Ain Shams University
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients aged 12 to 60 years old presenting with anterior or posterior chest wall swelling and/or palpable tenderness upon examination without any significant past medical history, or with history of recurrent chest infection or multiple minor chest trauma. Ultrasound of the sternocostal swellings was required to exclude other pathologies but no specific ultrasound finding was required to confirm the clinical diagnosis. Two senior thoracic surgeons were required to establish the diagnosis.

Exclusion criteria

Exclusion criteria: 1. Patients diagnosed with myositis, coronary syndrome, chest wall tumors or mediastinal syndrome as diagnosed by clinical examination, CT chest, MRI chest or chest ultrasound. 2. Traumatic muscle pain, arthritis of sternoclavicular/sternomanubrial joints and fibromyalgia of costochondral junction. 3. Refused to be enrolled in the study or did not complete the full assessment at all time intervals.

Design outcomes

Primary

MeasureTime frame
1. Pain measured using the NRS at 1, 2, 3 weeks and follow up period 2. Quality of life measured using the EURO 5Q-5D-5L score at 3 weeks

Secondary

MeasureTime frame
Size of joint swelling measured by patient interview at 3 weeks and 6 months after treatment.

Countries

Egypt

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 12, 2026