Postprandial glycaemic response and metabolic health in adults with and without increased metabolic risk Nutritional, Metabolic, Endocrine
Conditions
Interventions
This is a randomised, controlled, crossover study comparing two bread interventions: sourdough bread (intervention) and white/yeast bread (control). Participants will be randomised to the order in whi
Sponsors
University College Dublin
Eligibility
Sex/Gender
All
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 20–45 years 2. Eligible for one of two cohorts: 2.1. Metabolically healthy adults, or 2.2. Adults with body mass index =30 kg/m² (metabolic health risk cohort) 3. Willing and able to attend two full-day (8-hour) study visits separated by =7 days 4. Willing to consume the provided bread test meals and to wear a glucose sensor for blood glucose monitoring 5. Able to provide written informed consent
Exclusion criteria
Exclusion criteria: 1. Diagnosed diabetes or other clinically significant metabolic disease 2. Use of medication known to affect glucose metabolism (e.g., glucose-lowering drugs, systemic corticosteroids) 3. Coeliac disease or wheat/gluten allergy/intolerance, or other food allergy relevant to the test breads 4. Gastrointestinal disease or major gastrointestinal surgery (excluding uncomplicated appendectomy) 5. Pregnancy or breastfeeding 6. Current smoker or high alcohol intake (as defined by the study team) 7. Acute illness at the time of study visits 8. Any condition that, in the investigator’s opinion, makes participation unsafe or affects study outcomes
Countries
Ireland
Contacts
Public ContactEmma Feeney
Outcome results
None listed