Musculoskeletal aging in the Geneva Retirees Cohort

The Geneva Retirees Cohort (GERICO) is a prospective observational cohort study of community-dwelling women and men recruited between 2008 and 2011 at the age of 65±1.4 yrs and followed longitudinally

Eligibility

Sex/Gender

All

Age

63 Years to 67 Years

Inclusion criteria

Inclusion criteria: 1. Recently retired workers from the Geneva area 2. Both genders 3. Age 63 to 67 years 4. Rural and urban communities

Exclusion criteria

Exclusion criteria: 1. History of cancer treated in the past 5 years 2. Chronic renal failure 3. Chronic liver or lung disease 4. Current corticosteroid therapy 5. Primary hyperparathyroidism 6. Paget disease of bone 7. Malabsorption 8. Any neurological or musculoskeletal condition affecting skeletal health

Design outcomes

Primary

Measure	Time frame
Incident fractures, assessed by face-to-face or and auto-administered questionnaires (clinical fractures) and vertebral fracture assessment (VFA) by DXA (morphometric vertebral fractures) at follow-up 1 (after 3 years) and 2 (after 6 years). Written confirmation (eg, discharge summary, radiologist report) will be requested.	—

Secondary

Measure	Time frame
1. Bone phenotype at baseline, follow-up 1 (after 3 years) and 2 (after 6 years) 1.1. Bone mineral density using DXA (lumbar spine, hip, radius) 1.2. Bone microstructure and strength using high resolution peripheral computerized tomography (HR-pQCT) at distal radius and tibia 2. Muscle phenotype at follow-up 1 and 2 2.1. Muscle mass and appendicular lean mass adjusted for height mass (kg/m2) using DXA. 2.2. Muscle function and physical performance 3. Falls in the past years of follow-up 1 and 2 4. Genotyping at baseline using exome chip 5. Biochemical measurements of bone and mineral metabolism at baseline, follow-up 1 and 2. 6. Nutrition (calcium and protein intakes) using a food frequency questionnaire at baseline, follow-up 1 and 2 7. Physical activity using a face-to-face administered questionnaire at baseline, follow-up 1 and 2 8. Ten-year fracture probability using FRAX tool at baseline, follow-up 1 and 2 9. Assessment of quality of life using auto-administered questionnaires at follow-up 2	—

Measure

Time frame

1. Bone phenotype at baseline, follow-up 1 (after 3 years) and 2 (after 6 years) 1.1. Bone mineral density using DXA (lumbar spine, hip, radius) 1.2. Bone microstructure and strength using high resolution peripheral computerized tomography (HR-pQCT) at distal radius and tibia 2. Muscle phenotype at follow-up 1 and 2 2.1. Muscle mass and appendicular lean mass adjusted for height mass (kg/m2) using DXA. 2.2. Muscle function and physical performance 3. Falls in the past years of follow-up 1 and 2 4. Genotyping at baseline using exome chip 5. Biochemical measurements of bone and mineral metabolism at baseline, follow-up 1 and 2. 6. Nutrition (calcium and protein intakes) using a food frequency questionnaire at baseline, follow-up 1 and 2 7. Physical activity using a face-to-face administered questionnaire at baseline, follow-up 1 and 2 8. Ten-year fracture probability using FRAX tool at baseline, follow-up 1 and 2 9. Assessment of quality of life using auto-administered questionnaires at follow-up 2

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Countries

Switzerland

Contacts

Public ContactEmmanuel Biver

Outcome results

None listed