Micronutrient deficiencies Nutritional, Metabolic, Endocrine Nutritional deficiency
Conditions
Interventions
Current interventions, as of 23/07/2026:
Patients will be randomly allocated to one of four groups:
1. Calcium plus vitamin D supplemented group (control group)
2. Calcium plus Fe and vitamin D supp
Sponsors
University of Chile (Chile)
Eligibility
Sex/Gender
All
Age
16 Years to 18 Years
Inclusion criteria
Inclusion criteria: Current inclusion criteria as of 18/01/2017: 1. Male or female 2. 16 - 18 years old 3. In good health 4. Sexual maturity rating of Tanner stage 5 Previous inclusion criteria: 1. Male or female 2. 16 - 17 years old 3. In good health 4. Sexual maturity rating of Tanner stage 5
Exclusion criteria
Exclusion criteria: 1. Use of vitamin supplements containing iron, zinc, calcium, vitamin D during the last 6 months prior the beginning of the trial 2. Known intolerance/allergy to iron, zinc, and calcium supplements 3. Smoking and alcohol abuse or dependence 4. Morbidity (excepting anemia defined as hemoglobin < 120 g/L) 5. Participation in previous studies particularly involving the administration of micronutrient supplements 6. Pregnant or planning a pregnancy during the study period 7. Breastfeeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Bone mineralization (as an outcome of Ca supplementation) 2. Iron nutrition status measured by: 2.1. Hemoglobin 2.2. Mean corpuscular volume 2.3. Zn protoporphyrin 2.4. Serum ferritin 2.5. Total iron binding capacity 2.6. Serum Iron 2.7. Hepcidin 2.8. Transferrin receptor 2.9. Transferrin saturation 2.10. Total body iron 3. Zinc nutrition status measured by circulating Zn levels | — |
Secondary
| Measure | Time frame |
|---|---|
| Not provided at time of registration | — |
Countries
Chile
Outcome results
None listed