Cycling for weight loss in an 'altitude simulation chamber'

Comparison of metabolic responses to low intensity cycling under normal and mildly reduced normabaric oxygen in women with overweight

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

ISRCTN

Registry ID

ISRCTN11842323

Enrollment

Registered

2021-05-25

Start date

2010-04-01

Completion date

Unknown

Last updated

2022-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

To raise oxidation of body fat during low intensity cycling in women willing to lose overweight Not Applicable

Interventions

Participants perform a 50-min protocol, enclosing phases of rest, cycling at a personalized low intensity and recovery, in an 'altitude simulation chamber', at two occasions within a period of 2 weeks

25m³) an upright bike ergometer combines with a "ventilated hood system" for open-circuit respiratory gas exchange of cyclists. The 20 participants were listed in alphabetical order o

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: 1. Women willing to lose overweight by low intensity exercise 2. Low active 3. 20 - 40 years of age

Exclusion criteria

Exclusion criteria: 1. Anemia 2. Type 1 or type 2 diabetes 3. Hypertension 4. Heart disease

Design outcomes

Primary

Measure	Time frame
Measured during periods of rest, cycling and recovery: 1. O2 consumption (VO2: mL O2/min) 2. CO2 production (VCO2: mL CO2/min) derived from differences in content of O2 and CO2 measured between air samples drawn from the inlet (ambient air in the chamber) and outlet (ambient air modified by respiration ) of a 'ventilated hood'. Both sample lines are analyzed simultaneously by a dual channel Servomex 4100 gas analyzer (Servomex, Zoetermeer, The Netherlands). Each channel accommodates a paramagnetic O2 transducer serially connected to an infrared CO2 transducer. Differences in content of O2 and CO2 between sample lines caused by respiration, down to 0.01 %, are measured accurately during ventilation of the hood with 250 L of ambient air per min. To this purpose the entire analogue output range of the transducers (20 mA, being converted to 10 mV) is calibrated for a linear measuring range of only 1.00 %. VO2 and VCO2 measured at the same timeoptimize accuracy of 'real-time' changes in metabolism regarding metabolic costs (~VO2) and substrate use (~ VCO2/ VO2) before, during and after cycling. Mean values of data collected at 20 sec intervals during 5 min are calculated for 4 phases within the cycling protocol: Rest (5-10 min), Initial cycling (22-27 min), Final cycling (35-40 min) and Recovery (40-45 min))	—

Measure

Time frame

Measured during periods of rest, cycling and recovery: 1. O2 consumption (VO2: mL O2/min) 2. CO2 production (VCO2: mL CO2/min) derived from differences in content of O2 and CO2 measured between air samples drawn from the inlet (ambient air in the chamber) and outlet (ambient air modified by respiration ) of a 'ventilated hood'. Both sample lines are analyzed simultaneously by a dual channel Servomex 4100 gas analyzer (Servomex, Zoetermeer, The Netherlands). Each channel accommodates a paramagnetic O2 transducer serially connected to an infrared CO2 transducer. Differences in content of O2 and CO2 between sample lines caused by respiration, down to 0.01 %, are measured accurately during ventilation of the hood with 250 L of ambient air per min. To this purpose the entire analogue output range of the transducers (20 mA, being converted to 10 mV) is calibrated for a linear measuring range of only 1.00 %. VO2 and VCO2 measured at the same timeoptimize accuracy of 'real-time' changes in metabolism regarding metabolic costs (~VO2) and substrate use (~ VCO2/ VO2) before, during and after cycling. Mean values of data collected at 20 sec intervals during 5 min are calculated for 4 phases within the cycling protocol: Rest (5-10 min), Initial cycling (22-27 min), Final cycling (35-40 min) and Recovery (40-45 min))

—

Secondary

Measure	Time frame
1. Blood oxygen saturation (SaO2: %) measured using pulse oximeter 2. Heart rate (HR: min-1) monitored by reflectance finger pulse-oxymetry using the PulseOx 7500 (SPO Medical, Simi Valley CA, USA) 3. Glucose (mM) measured using a single sample of 10 µL fingertip capillary blood using a Biosen C-line analyzer (EKF Diagnostics, Sopachem, Ochten, The Netherlands) 4. Lactate (mM) measured using a single sample of 10 µL fingertip capillary blood using a Biosen C-line analyzer (EKF Diagnostics, Sopachem, Ochten, The Netherlands) 5. Rate of perceived exertion (RPE value: Borg scale: 6 – 20) All secondary outcome measures are collected at min 6, 26, 39 and 46 and assumed to represent the 4 phases of the cycling protocol mentioned under primary outcome measures	—

Measure

Time frame

1. Blood oxygen saturation (SaO2: %) measured using pulse oximeter 2. Heart rate (HR: min-1) monitored by reflectance finger pulse-oxymetry using the PulseOx 7500 (SPO Medical, Simi Valley CA, USA) 3. Glucose (mM) measured using a single sample of 10 µL fingertip capillary blood using a Biosen C-line analyzer (EKF Diagnostics, Sopachem, Ochten, The Netherlands) 4. Lactate (mM) measured using a single sample of 10 µL fingertip capillary blood using a Biosen C-line analyzer (EKF Diagnostics, Sopachem, Ochten, The Netherlands) 5. Rate of perceived exertion (RPE value: Borg scale: 6 – 20) All secondary outcome measures are collected at min 6, 26, 39 and 46 and assumed to represent the 4 phases of the cycling protocol mentioned under primary outcome measures

—

Countries

Netherlands

Contacts

Public ContactVictor Schreurs

vs@glazenkamp.net+31.24.3531507

Outcome results

None listed

Source: ISRCTN (via WHO ICTRP) · Data processed: Feb 4, 2026