Bilateral oral lichen planus lesions Skin and Connective Tissue Diseases Lichen planus
Conditions
Interventions
This study is a split-mouth randomised clinical trial. Participants are randomised by coin toss to decide which side of their mouth is to be treated by injectable platelet-rich fibrin and which is to
Sponsors
Damascus University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Patients diagnosed with oral lichen planus lesions
Exclusion criteria
Exclusion criteria: 1. Patients with systemic disease 2. A history of topical therapy for oral lichen planus in the last 2 weeks or systemic treatment for oral lichen planus in the last 3 months 3. Pregnancy or lactation 4. Patients who had taken immunodepressant drugs the past 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pain measured using a Visual Analog Scale (VAS) once a week during treatment for 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Clinical presentation of oral lichen planus measured using the REU scoring system at 1, 2, 3 and 4 weeks 2. Treatment response: surface areas of erythema and ulceration measured with a sterile flexible periodontal scale probe at 1, 2, 3 and 4 weeks 3. Recurrence rate measured by clinical examination at the end of treatment (day 30) 4. Quality of life measured using OHIP- 14 before treatment and at the end of treatment (day 30) | — |
Countries
Syria
Outcome results
None listed