Obesity Nutritional, Metabolic, Endocrine Obesity
Conditions
Interventions
Non-diabetic patients with severe obesity (that is, BMI >40 kg/m. or BMI >35 kg/m. with comorbidities) will be randomized into two groups receiving either gastric bypass (RYGB) or gastric sleeve. Pati
Sponsors
Södertälje Sjukhus
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1. Obese non-diabetic females 2. 18-65 years of age 3. Signed informed consent form
Exclusion criteria
Exclusion criteria: 1. Type 2 diabetes 2. Any history of receiving GLP-1 analogues or DPP-4 inhibitors 3. Previous treatment with insulin (any regimen) within 3 months 4. Current or history of drug and alcohol abuse
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Plasma GLP-1, measured using the meal tolerance test and GLP-1 specific ELISA of serum samples 2. Gut microbiota composition, analyzed from fecal samples Timepoints: before 10-day diet, after 10-day diet/before surgery, 3 months after surgery, 6 months after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Plasma inflammatory markers, analyzed by specific ELISAs 2. Lipid profile, determined by commercially available HDL and LDL/VLDL Cholesterol Assay Kits, Free Fatty Acid Quantification Kit, as well as Triglyceride Quantification Kit Timepoints: before 10-day diet, after 10-day diet/before surgery, 3 months after surgery, 6 months after surgery | — |
Countries
Sweden
Outcome results
None listed